ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Anti-tuberculous mycobacterium leprae drugs Pasiniazid

Pasiniazid

Pasiniazid Basic information
Product Name:Pasiniazid
Synonyms:isonicotinic acid hydrazide 4-aminosalicylate;ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT;PASINIAZID;isonicotinicacidhydrazidep-*aminosalicylate;PASINIAZIDISONIAZID AMINOSALICYLATE UV;Dipasic;Fintozid;Nidrapas
CAS:2066-89-9
MF:C13H14N4O4
MW:290.27
EINECS:218-183-2
Product Categories:Pharmaceutical Intermediates
Mol File:2066-89-9.mol
Pasiniazid Structure
Pasiniazid Chemical Properties
Melting point 142-144°
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Water
form neat
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36/37
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
Pasiniazid Usage And Synthesis
OriginatorPasinazid, Yick-Vic Chemicals
Usesantibacterial (tuberculostatic)
UsesPasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM).
Manufacturing Process10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative


Therapeutic FunctionAntitubercular
Pasiniazid Preparation Products And Raw materials
Raw materials4-Aminosalicylic acid-->Isoniazid-->pecilocin
5-Aminosalicylic acid Protionamide Rifapentine COD LIVER OIL Pyrazinamide Rifampicin Ketoconazole 4-Aminosalicylic acid Isonicotinic acid Pasiniazid METHYL 4-AMINOSALICYLATE antioxidant 1024 Isoniazid NICOTINIC ACID HYDRAZIDE PYRIDIN-4-YLMETHYL-HYDRAZINE Isonicotinamide Sodium 4-aminosalicylate dihydrate
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