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N-Fmoc-8-Aminooctanoic acid

N-Fmoc-8-Aminooctanoic acid Basic information
Product Name:N-Fmoc-8-Aminooctanoic acid
Synonyms:N-FMOC-8-AMINOOCTANOIC ACID;N-(9-FLUORENYLMETHYLOXYCARBONYL)-8-AMINO-OCTANOIC ACID;N-(9-FLUORENYLMETHOXYCARBONYL)-8-AMINOCAPRYLIC ACID;N-(9-FLUORENYLMETHOXYCARBONYL)-8-AMINOOCTANOIC ACID;N-ALPHA-FMOC-8-AMINOOCTANOIC ACID;RARECHEM EM WB 0026;FMOC-NH-(CH2)7-COOH;FMOC-AOC(8)-OH
CAS:126631-93-4
MF:C23H27NO4
MW:381.46
EINECS:
Product Categories:amino;Amino Acids
Mol File:126631-93-4.mol
N-Fmoc-8-Aminooctanoic acid Structure
N-Fmoc-8-Aminooctanoic acid Chemical Properties
Melting point 118-119 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boiling point 597.7±33.0 °C(Predicted)
density 1.174±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka4.77±0.10(Predicted)
form Powder
color White
BRN 8286497
CAS DataBase Reference126631-93-4(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HazardClass IRRITANT
HS Code 29242990
MSDS Information
ProviderLanguage
SigmaAldrich English
N-Fmoc-8-Aminooctanoic acid Usage And Synthesis
DescriptionN-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical PropertiesWhite powder
N-Fmoc-8-Aminooctanoic acid Preparation Products And Raw materials
Preparation Products8-Aminooctanoic acid
1,1'-Carbonyldiimidazole 8-Aminooctanoic acid Hyaluronic acid N-alpha-FMOC-Nepsilon-BOC-L-Lysine Fmoc-Asp(OtBu)-OH Carbonyl iron powder CARBONYL SULFIDE Folic acid Nalpha-Fmoc-Ndelta-trityl-L-glutamine 6-Aminocaproic acid Octanoic acid Glycine L-Fmoc-Aspartic acid alpha-tert-butyl ester 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH Fmoc N-(9-Fluorenylmethoxycarbonyloxy)succinimide Citric acid
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