Fmoc-Asp(OtBu)-OH

Fmoc-Asp(OtBu)-OH Basic information

Product Name:	Fmoc-Asp(OtBu)-OH
Synonyms:	NALPHA-9-Fluorenylmethoxycarbonyl-L-aspartic acid B-tert- butyl ester;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-ASPARTIC ACID-4-TERT-BUTYL ESTER;Fmoc-L-aspartic acid -t-butyl ester;N-α-Fmoc-L-aspartic acid β-tert butyl ester;L-Aspartic Acid-15N-β-O-t-Butyl Ester-N-FMOC;4-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate;4-tert-Butyl N-Fmoc-L-aspartate;N-Fmoc-L-aspartic Acid 4-tert-Butyl Ester
CAS:	71989-14-5
MF:	C23H25NO6
MW:	411.45
EINECS:	276-251-7
Product Categories:	Amino Acids;Aspartic acid [Asp, D];Fmoc-Amino Acids and Derivatives;PROTECTED AMINO ACID & PEPTIDES;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series
Mol File:	71989-14-5.mol

Fmoc-Asp(OtBu)-OH Chemical Properties

Melting point	148-150 °C (dec.)
alpha	-25 º (c=1,DMF 24 ºC)
Boiling point	530.45°C (rough estimate)
density	1.2498 (rough estimate)
refractive index	-25 ° (C=1, DMF)
storage temp.	2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder to crystal
pka	3.57±0.23(Predicted)
color	White to Almost white
optical activity	[α]20/D 24±2°, c = 1% in DMF
Water Solubility	Slightly soluble in water.
BRN	3635671
InChIKey	FODJWPHPWBKDON-IBGZPJMESA-N
CAS DataBase Reference	71989-14-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36/37/39-27-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29242990

MSDS Information

Provider	Language
FMOC-L-Aspartic acid beta-tert-butyl ester	English
SigmaAldrich	English
ACROS	English

Fmoc-Asp(OtBu)-OH Usage And Synthesis

Chemical Properties	Fmoc-Asp(OtBu)-OH is a protected form of L-aspartic acid. It is a white to light yellow crystal powder. The molecule contains ester groups and amino groups, making it prone to polymerization and unstable over time. Therefore, it is not recommended to store it for extended periods.
Uses	L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body.
Preparation	Fmoc-Asp(OtBu)-OH was prepared by substitution reaction with 9-fluorenylmethyl chloroformate from L-aspartic acid 4-tert-butyl ester.
General Description	The product number for this product was previously 04-12-1013. To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Fmoc-Asp(OtBu)-OH Preparation Products And Raw materials

Raw materials	tert-Butyl acetate-->L-ASPARTIC ACID-->L-Aspartic acid 4-tert-butyl ester-->9-Fluorenylmethyl chloroformate
Preparation Products	FMOC-ASPARTIMOL(OTBU)-->ANGIOTENSIN I, HUMAN-->CYCLO (ARG-GLY-ASP-D-PHE-LYS)-->(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate-->L-Aspartic acid-->ANGIOTENSIN II, HUMAN-->FMOC-ASP(OBUT)-NH2

N-ALPHA-FMOC-D-ASPARTIC ACID BETA-TERT-BUTYL ESTER,Fmoc-D-Aspartic acid beta-tert-butyl ester FMOC-ASP(O-1-ADA)-OH N-ALPHA-FMOC-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER PENTAFLUOROPHENYL ESTER FMOC-ASP(O-2-PHIPR)-OH Carbonyl iron powder Fmoc-Asp(OBut)-ODhbt Fmoc-Aib-OH Poly-L-aspartic acid Fmoc-L-aspartic acid L-Aspartic-15N acid, N-Fmoc, 4-tert-butyl ester FMOC-L-ASP(OTBU)-O-CH2-PHI-OCH2-CH2-COOH L-ASPARTIC ACID Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester FMOC-ASP(OTBU)-OSU Fmoc AcidEster FMOC-ASN(TRT)-OPFP FMOC-ASP(OTBU)-2-CHLOROTRITYL RESIN

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