Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Basic information

Product Name:	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
Synonyms:	BUTTPARK 45\03-53;ETHYL 4-CHLORO-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE;ETHYL 4-CHLORO-2-METHYLTHIOPYRIMIDINE-5-CARBOXYLATE;ETHYL 4-CHLORO-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE;2-METHYLTHIO-4-CHLORO-5-ETHOXYCARBONYLPYRIMIDINE;4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester;ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl;SIEHE AV22429
CAS:	5909-24-0
MF:	C8H9ClN2O2S
MW:	232.69
EINECS:	227-619-0
Product Categories:	Pyrimidines;Nucleotides and Nucleosides;APIs & Intermediate;Pyrimidine;Bases & Related Reagents;Heterocycle-Pyrimidine series;Pyrimidine series;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;5909-24-0
Mol File:	5909-24-0.mol

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Chemical Properties

Melting point	60-63 °C (lit.)
Boiling point	132°C/0.4mmHg(lit.)
density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate
pka	-2.19±0.29(Predicted)
form	Crystalline Powder
color	White to light yellow to beige
InChIKey	SNNHLSHDDGJVDM-UHFFFAOYSA-N
CAS DataBase Reference	5909-24-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate	English
SigmaAldrich	English
ALFA	English

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Usage And Synthesis

Chemical Properties	off white to light yellow solid
Uses	A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae
Uses	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate was used in the synthesis of pyrimidinopyridones, potential inhibitors of the FMS tyrosine kinase.

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium-->Thionyl chloride-->Phosphorus oxychloride-->Potassium hydroxide-->Acetic anhydride-->Benzene-->Triethyl orthoformate-->Diethyl malonate-->2-Methyl-2-thiopseudourea sulfate-->Diethyl ethoxymethylenemalonate
Preparation Products	4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde-->(4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL-->5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]--->4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde-->4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

Login