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| | Benidipine Basic information |
| Product Name: | Benidipine | | Synonyms: | (R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;NACADIPINE;BENIDIPINE;BENIDIPINE HCL;CAPADIPINE;CONIEL;KW-3049 | | CAS: | 105979-17-7 | | MF: | C28H31N3O6 | | MW: | 505.56 | | EINECS: | 857-680-4 | | Product Categories: | Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical | | Mol File: | 105979-17-7.mol |  |
| | Benidipine Chemical Properties |
| Boiling point | 625.2±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | pKa 7.34(H2O(long extrapolation)
) (Uncertain) | | Water Solubility | 316μg/L at 25℃ | | LogP | 4.61 | | CAS DataBase Reference | 105979-17-7(CAS DataBase Reference) |
| | Benidipine Usage And Synthesis |
| Uses | Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive. | | Enzyme inhibitor | This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM. |
| | Benidipine Preparation Products And Raw materials |
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