(R)-(-)-alpha-Methoxyphenylacetic acid

(R)-(-)-alpha-Methoxyphenylacetic acid Basic information
Product Name:(R)-(-)-alpha-Methoxyphenylacetic acid
Synonyms:(R)-(-)-METHOXYPHENYLACETIC ACID;O-METHYL-D-MANDELIC ACID;(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-(-)-A-METHOXYPHENYLACETIC ACID;Benzeneacetic acid, alpha-methoxy-, (R)-;Acetic acid, methoxyphenyl- (8CI);Benzeneacetic acid, .a
CAS:3966-32-3
MF:C9H10O3
MW:166.17
EINECS:223-580-9
Product Categories:Analytical Chemistry;Carboxylic Acids (Chiral);Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination;Synthetic Organic Chemistry
Mol File:3966-32-3.mol
(R)-(-)-alpha-Methoxyphenylacetic acid Structure
(R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties
Melting point 66-68 °C(lit.)
alpha -160.4 º (C=1, MEOH)
Boiling point 164-166°C 18mm
density 1.1708 (rough estimate)
refractive index -147 ° (C=0.5, EtOH)
Fp 164-166°C/18mm
storage temp. 2-8°C
solubility Chloroform, Ethanol, Methanol
pka3.10±0.10(Predicted)
form Fine Crystalline Powder or Needles
color White
optical activity[α]20/D -150±3°, c = 0.5% in ethanol
BRN 3589257
CAS DataBase Reference3966-32-3(CAS DataBase Reference)
NIST Chemistry Reference(R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29189900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
(R)-(-)-alpha-Methoxyphenylacetic acid Usage And Synthesis
Chemical Propertieswhite fine crystalline powder or needles
Uses(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.
General Description(R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers.
Purification MethodsPurify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]
(R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials
Raw materialsDL-alpha-Methoxyphenylacetic acid
(R)-(-)-alpha-Methoxyphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate DL-Mandelic acid (3,4-Dimethoxyphenyl)acetic acid 2-Hydroxyphenylacetic acid diphenylethoxy-aceticaci Folic acid 4-Methoxyphenylacetic acid α-Lipoic Acid Glycine 3,5-dimethoxyphenylacetic acid diphenylmethoxyacetic acid 4-Hydroxyphenylacetic acid (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid PARGEVERINE HCL phosphoric acid Pipoxolan Hcl Phenylacetic acid

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.