Azatadine

Azatadine Basic information

Product Name:	Azatadine
Synonyms:	6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-methylpiperidin-4-ylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-;AZATADINE;Desloratadine Impurity 25;11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;Azatadine USP/EP/BP
CAS:	3964-81-6
MF:	C20H22N2
MW:	290.4
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	3964-81-6.mol

Azatadine Chemical Properties

Melting point	124-126°
Boiling point	450.1±45.0 °C(Predicted)
density	1.127
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Powder
pka	8.74±0.20(Predicted)

Safety Information

MSDS Information

Azatadine Usage And Synthesis

Uses	Antihistaminic.
Definition	ChEBI: A benzo[5,6]cyclohepta[1,2-b]pyridine having a 1-methylpiperidin-4-ylidene group at the 11-position.
Brand name	Optimine (Schering).

Azatadine Preparation Products And Raw materials

Raw materials

2-Pyridinecarbonitrile, 3-(2-phenylethyl)--->5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one-->6-11-dihydro-11-(1-methylpiperidin-4-yl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol-->N-T-BUTYL-3-METHYL PYRIDINE-2-CARBOXAMIDE-->1-Methylpiperdin-4-ylmagnesium chloride, 0.50 M in THF-->Benzyl chloride-->N-Methyl Desloratadine

3-METHOXY-N-METHYLDESLORATADINE Rupatadine Azatadine LORATADINE-D4 CARBOPROPOXY LORATADINE 4-Hydroxymethyl Loratadine Loratadine 2-Hydroxymethyl Loratadine Loratadine EP Impurity E 2-Formyl Loratadine 4-Formyl Loratadine N-Methyl Desloratadine 4-(8-CHLORO-5,6-DIHYDRO-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-PIPERIDINE-1-CARBONITRILE 3-Methoxy Loratadine

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