ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Basic information
Product Name:(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms:CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE);cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride;cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%;cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride;(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE;(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE);(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-
CAS:1062580-52-2
MF:C14H23ClN2
MW:254.8
EINECS:
Product Categories:1
Mol File:Mol File
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Structure
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties
Melting point 249～251℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form Solid
color White to Off-White
InChIInChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKeyFVRZQLQXDPJADE-WLZBWWFYNA-N
SMILESC(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|
Safety Information
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Usage And Synthesis
Uses(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses(3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Hydrochloride is a related compound of Tofacitinib (T528000). (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Hydrochloride can be used to prepare janus kinase 1 selective inhibitor.
SynthesisSynthesis_1062580-52-2
The TiCl4(0.2g, 1mmol), NEt3(0.15g, 1 . 5mmol) suspended 200 ml in toluene, then add 1-benzyl-4-methyl-3-ketone piperidine (20.3g, 100mmol), temperature control 35 ??C methylamine solution is added to the reaction solution (9.32g, 120mmol) reaction 4 hours, adding NaBH (OAC) 3 (0.32g, 1 . 5mmol), glacial acetic acid 2 ml, temperature control 35 ??C reaction, thin layer monitoring after the reaction is complete. Adding saturated salt water washing, anhydrous sodium sulfate for drying the organic phase, the organic phase concentrated, with residues 35% hydrochloric acid ethanol re-crystallization, to obtain (3R, 4R)-cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride 17.2g, yield 85.0%, optical purity 99.0% (HPLC method).
3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile Methyl (4-Methylpiperidin-3-yl)carbaMate N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]- 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 13-Deoxyepirubicin Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 3-bis(4-Methylbenzoyloxy)succinate) 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib citrate (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
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