ChemicalBook Product Catalog Pharmaceutical intermediates N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol Basic information
Product Name:N-Boc-4-piperidinemethanol
Synonyms:1-N-BOC-4-HYDROXYMETHYL-PIPERIDINE;1-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE;1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL;TERT-BUTYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;TERT-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;N-T-BUTOXYCARBONYL-HEXAHYDROISONICOTINOL;N-T-BUTOXYCARBONYL-4-HYDROXYMETHYL-PIPERIDINE;N-T-BUTOXYCARBONYL-4-PIPECOLINOL
CAS:123855-51-6
MF:C11H21NO3
MW:215.29
EINECS:628-428-9
Product Categories:Piperidine Series;Heterocycles;Amines;blocks;Piperidine;Piperazine;123855-51-6
Mol File:123855-51-6.mol
N-Boc-4-piperidinemethanol Structure
N-Boc-4-piperidinemethanol Chemical Properties
Melting point 78-82 °C (lit.)
Boiling point 308.0±15.0 °C(Predicted)
density 1.059±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka14.94±0.10(Predicted)
form Powder
color White to brown
InChIInChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
InChIKeyCTEDVGRUGMPBHE-UHFFFAOYSA-N
SMILESN1(C(OC(C)(C)C)=O)CCC(CO)CC1
CAS DataBase Reference123855-51-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 24/25
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
N-Boc-4-piperidinemethanol Usage And Synthesis
Chemical PropertiesWhite to light brown solid
UsesN-Boc-4-piperidinemethanol is an important piperidine derivative, which can be used in organic synthesis and pharmaceutical intermediates, It may be used to synthesize:
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
N-Boc-4-piperidinecarboxaldehyde
[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.
ApplicationN-Boc-4-piperidinemethanol is a curcumin analogue that binds to the epidermal growth factor receptor (EGFR) and prevents the binding of ligands. In vitro studies have shown that it can inhibit tumor growth and induce apoptosis in cancer cells. The drug is also capable of inhibiting the proliferation of normal cells, which may be due to its ability to recruit EGFR from outside the cell membrane. This process triggers signaling events that lead to cell death.
General DescriptionN-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.
N-Boc-4-piperidinemethanol Preparation Products And Raw materials
Preparation ProductsTERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE-->4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER -->N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE-->1-Boc-4-(aminomethyl)piperidine-->tert-butyl 4-(chloromethyl)piperidine-1-carboxylate-->tert-butyl 4-(4-bromophenoxymethyl)piperidine-1-carboxylate
N-Boc-Piperidine-4-carboxylic acid methyl ester N-(tert-Butoxycarbonyl)-4-piperidone BOC-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID N-BOC-4-ISO-PROPYL-4-PIPERIDINECARBOXYLIC ACID N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID N-Boc-4-piperidinemethanol 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER tert-Butyl acetate Diphenoxylate N-BOC-4-ETHYL PIPERIDINECARBOXYLATE 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester tert-Butanol 4-Piperidinemethanol tert-Butyl peroxyacetate PHENCYCLIDINE-D5 HYDROCHLORIDE Haloperidol DROPERIDOL
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