ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-Hydroxyisophthalonitrile

4-Hydroxyisophthalonitrile

4-Hydroxyisophthalonitrile Basic information
Product Name:4-Hydroxyisophthalonitrile
Synonyms:Febuxostat 30;Febuxostat-13;Febuxostat Impurity 20/4-hydroxyisophthalonitrile;4-hydroxybenzene-1,3-dicarbonitrile;2,4-DIAMINO-PHENOL;2,4-Dicyanophenol;4-Hydroxyisophthalonitrile;FeBuxostat Impurity 35
CAS:34133-58-9
MF:C8H4N2O
MW:144.13
EINECS:
Product Categories:
Mol File:Mol File
4-Hydroxyisophthalonitrile Structure
4-Hydroxyisophthalonitrile Chemical Properties
Boiling point 319℃
density 1.34
Fp 150℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka5.04±0.18(Predicted)
form Solid
color Pale Beige
Safety Information
HS Code 2926907090
MSDS Information
4-Hydroxyisophthalonitrile Usage And Synthesis
Uses4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.
4-Hydroxyisophthalonitrile Preparation Products And Raw materials
Preparation ProductsDIMETHYL 4-HYDROXYISOPHTHALATE
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide Febuxostat Impurity 8 isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 4-(2-Methylpropoxy)-1,3-benzenedicarbonitrile Febuxostat Acyl-β-D-glucuronide Febuxostat Descyano Impurity 4-HYDROXYTHIOBENZAMIDE Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid 1-Bromo-2-methylpropane 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate 4-Aminophenol Febuxostat Impurity 46 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid
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