Butenafine

Butenafine Basic information
Product Name:Butenafine
Synonyms:n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;BUTENAFINE;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
CAS:101828-21-1
MF:C23H27N
MW:317.47
EINECS:
Product Categories:
Mol File:101828-21-1.mol
Butenafine Structure
Butenafine Chemical Properties
Melting point 200-202 °C
Boiling point 426.1±14.0 °C(Predicted)
density 1.032±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM)
pka7.87±0.50(Predicted)
Water Solubility Water: Insoluble
LogP6.770 (est)
CAS DataBase Reference101828-21-1(CAS DataBase Reference)
Safety Information
MSDS Information
Butenafine Usage And Synthesis
UsesButenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.
Butenafine (Mentax)
DefinitionChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Brand nameLotrimin (Schering); Mentax (Mylan Bertek).
Butenafine Preparation Products And Raw materials
Bendazac L-lysine Ciclopirox ethanolamine 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Tolnaftate Clobetasol propionate Nitric acid Butenafine hydrochloride Fenticonazole nitrate Ketoconazole Pranoprofen Florfenicol Terbinafine Hydrochloride Butenafine AKOS 216-17 AKOS 216-16 1-NAPHTHALENEMETHYLAMINE BENZYL-(4-TERT-BUTYL-BENZYL)-AMINE BENZYL-(4-ISOPROPYL-BENZYL)-AMINE

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