Ethyl 2-oxocyclopentanecarboxylate

Ethyl 2-oxocyclopentanecarboxylate Basic information
Product Name:Ethyl 2-oxocyclopentanecarboxylate
Synonyms:ETHYL-2-CYCLOPENTANONECARBOXYLATE;ETHYL 2-OXOCYCLOPENTANECARBOXYLATE;CYCLOPENTANONE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-oxocyclopentanecarboxylate, tech., 90% 100GR;Ethyl 2-oxocyclopentanecarboxylate, tech., 90% 25GR;2-Carbethoxycyclopentanone 2-Ethoxycarbonylcyclopentanone Cyclopentanone-2-carboxylic Acid Ethyl Ester Ethyl Cyclopentanone-2-carboxylate 2-Oxocyclopentanecarboxylic Acid Ethyl Ester;Ethyl 2-oxocyclopentanecarboxylate,2-(Ethoxycarbonyl)cyclopentanone, Ethyl cyclopentanone-2-carboxylate;Ethyl-2-cyclopentanonecarboxylate 10g [611-10-9]
CAS:611-10-9
MF:C8H12O3
MW:156.18
EINECS:210-253-0
Product Categories:Pharmaceutical Intermediates;BUILDING BLOCKS;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, functional materials
Mol File:611-10-9.mol
Ethyl 2-oxocyclopentanecarboxylate Structure
Ethyl 2-oxocyclopentanecarboxylate Chemical Properties
Boiling point 102-104 °C/11 mmHg (lit.)
density 1.054 g/mL at 25 °C (lit.)
refractive index n20/D 1.452(lit.)
Fp 172 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
pka12.02±0.20(Predicted)
color Clear colorless to pale yellow
Water Solubility insoluble
BRN 387787
InChIKeyJHZPNBKZPAWCJD-UHFFFAOYSA-N
LogP0.330 (est)
CAS DataBase Reference611-10-9(CAS DataBase Reference)
NIST Chemistry ReferenceCyclopentanecarboxylic acid, 2-oxo-, ethyl ester(611-10-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 23-24/25-36/37-26
WGK Germany 3
10
HazardClass IRRITANT
HS Code 29183000
MSDS Information
ProviderLanguage
2-(Ethoxycarbonyl)cyclopentanone English
SigmaAldrich English
ACROS English
ALFA English
Ethyl 2-oxocyclopentanecarboxylate Usage And Synthesis
Chemical Propertiesclear colourless to pale yellow liquid
UsesPharmaceutical intermediate.
UsesEthyl 2-oxocyclopentanecarboxylate was used in stereoselective synthesis of (±)-cis,cis-spiro[4.4]nonane-1,6-diol. It was also used in the synthesis of tanikolide.
Synthesis Reference(s)Journal of the American Chemical Society, 85, p. 207, 1963 DOI: 10.1021/ja00885a021
The Journal of Organic Chemistry, 55, p. 5037, 1990 DOI: 10.1021/jo00304a014
Tetrahedron Letters, 22, p. 1353, 1981 DOI: 10.1016/S0040-4039(01)90316-8
General DescriptionPhase-transfer benzylation reaction of ethyl 2-oxocyclopentanecarboxylate with benzyl bromide in microreactor has been investigated. Ethyl 2-oxocyclopentanecarboxylate participates in cobalt (II) Schiff′s base complex catalyzed oxidation of primary and secondary alcohols.
HazardVapors are toxic, as is skin contact.
Cyclohexanecarboxylic acid BUTYL 2-CYCLOPENTANONE-1-CARBOXYLATE Benzocaine Ethyl 2-oxocyclopentanecarboxylate 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Triethyl orthoformate ETHYL (-)-CAMPHORCARBOXYLATE Urethane Poly-AminoEthylFormate Ethylparaben 2-CYCLOPENTANONECARBOXYLIC ACID ISOXADIFEN-ETHYL ETHYL1-(2-(ETHOXYCARBONYL)ETHYL)-2-OXOCYCLOPENTANECARBOXYLATE Cyclopentanecarboxylic acid Ethyl propiolate Cyclopropanecarboxylic acid Ethyl cyanoformate (+)-CAMPHORCARBOXYLIC ACID ETHYL ESTER

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