ChemicalBook Product Catalog Biochemical Engineering Polypeptide N-acetyl aspartyl-glutaMic acid

N-acetyl aspartyl-glutaMic acid

N-acetyl aspartyl-glutaMic acid Basic information
Product Name:N-acetyl aspartyl-glutaMic acid
Synonyms:SPAGLUMIC ACID;NAAG;N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID;N-ACETYLASPARTYLGLUTAMIC ACID;N-ACETYL-ASP-GLU;N-ACETYL-ASP-GLU-OH;ALPHA-NAAG;AC-ASP-GLU
CAS:3106-85-2
MF:C11H16N2O8
MW:304.25
EINECS:
Product Categories:
Mol File:3106-85-2.mol
N-acetyl aspartyl-glutaMic acid Structure
N-acetyl aspartyl-glutaMic acid Chemical Properties
Melting point 171-173 °C
Boiling point 769.5±60.0 °C(Predicted)
density 1.472±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility H2O: 50 mg/mL
form powder
pka3.04±0.10(Predicted)
color white
optical activity[α]22/D 34.5°, c = 1.1 in H2O(lit.)
Water Solubility Soluble to 100 mM in water
Stability:Hygroscopic
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29241990
MSDS Information
ProviderLanguage
SigmaAldrich English
N-acetyl aspartyl-glutaMic acid Usage And Synthesis
Chemical PropertiesWhite powder
UsesN-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
UsesN-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.
DefinitionChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.
General DescriptionNAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.
Biochem/physiol ActionsEndogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
storage-20°C
N-acetyl aspartyl-glutaMic acid Preparation Products And Raw materials
Preparation ProductsL-Glutamic acid
MGVRNSVLSGKKADE AC-DEVD-AMC NAAG, [GLUTAMATE-3,4-3H]- N-acetyl aspartyl-glutaMic acid Caspase 8 Colorimetric Substrate (FLICE, MASH, Mch5, N-acetyl-Asp-Glu-Val-Asp-pNA (p-nitroanilide)) Caspase 8 Fluorometric Substrate, IETD-AFC (FLICE, MASH, Mch5, N-acetyl-Asp-Glu-Val-Asp-AFC N-ACETYL-ASP-GLU-VAL-ASP-P-NITROANILIDE PNA,N-ACETYL-ASP-GLU-VAL-ASP-P-NITROANILIDE,ACETYL-ASP-GLU-VAL-ASP-(P-NITROANILIDE) PROTEIN PHOSPHATASE 2A/A (7-19) BLOCKING PEPTIDE ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE,N-ACETYL-ASP-GLU-VAL-ASP-AL,N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE),N-acetyl-Asp-Glu-Val-Asp-Ala MCA-ASP-GLU-VAL-ASP-ALA-PRO-LYS(DNP)-OH Caspase 8 Fluorometric Substrate, IETD-AFC N-acetyl-Asp-Glu-Val-Asp-AFC, 7-amino-4-trifluoromethyl coumarin) (FLICE, MASH, Mch5, AC-DEVD-AFC H-VAL-GLY-ASP-GLU-OH MAP KINASE ERK3 (303-325) BLOCKING PEPTIDE, RAT N-ACETYL-ASP-GLU-HIS-ASP-7-AMINO-4-METHY Caspase 8 Colorimetric Substrate, N-acetyl-Asp-Glu-Val-Asp-pNA p-nitroanilide (FLICE, MASH, Mch5) N-ACETYL-ASP-GLU-HIS-ASP-7-AMIDO-4-METHYLCOUMARIN TRIFLUOROACETATE SALT ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE,N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE),N-ACETYL-ASP-GLU-VAL-ASP-AL
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