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| | 5-Amino-2-nitrobenzoic acid Basic information |
| | 5-Amino-2-nitrobenzoic acid Chemical Properties |
| Melting point | 236-238 °C (lit.) | | Boiling point | 481.3±35.0 °C(Predicted) | | density | 1.568±0.06 g/cm3(Predicted) | | vapor pressure | 0-0Pa at 20-50℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO, Methanol | | pka | 2.28±0.25(Predicted) | | form | Solid | | color | Yellow-Brown | | Water Solubility | Insoluble | | BRN | 2107512 | | InChIKey | KZZWQCKYLNIOBT-UHFFFAOYSA-N | | LogP | -1.48 at pH7 | | Surface tension | 70.53mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 13280-60-9(CAS DataBase Reference) |
| | 5-Amino-2-nitrobenzoic acid Usage And Synthesis |
| Chemical Properties | Yellow Powder | | Uses | Reactant for:
- Two-component dendritic chain reactions
- Enzymic activation of hydrophobic self-immolative dendrimers
- Preparation of insulin receptor tyrosine kinase activator
- Preparation of polymer-bound diazonium salts using Merrifield resin-bound piperazine
| | Application | 5-Amino-2-nitrobenzoic acid is a drug that has been shown to inhibit the activity of proteases. It has been used to detect the presence of protease activity in urine samples, as well as to study the inhibition of protease activity by other drugs. It is an inhibitor of chymotrypsin, trypsin, and elastase. This drug has been shown to be effective in inhibiting these enzymes at low concentrations, with a detection sensitivity of approximately 0.1 μM. It inhibits the growth of bacteria by binding to them and preventing protein synthesis. The compound also inhibits the enzyme dihydrolipoamide dehydrogenase in mitochondria, which is required for cellular respiration and energy production. | | Purification Methods | Crystallise the acid from water. [Beilstein 14 III 1021.] |
| | 5-Amino-2-nitrobenzoic acid Preparation Products And Raw materials |
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