|
| | 2-Amino-1,3-propanediol Chemical Properties |
| Melting point | 52-55 °C (lit.) | | Boiling point | 277 °C (lit.) | | density | 1.1278 (rough estimate) | | vapor pressure | 0.01Pa at 25℃ | | refractive index | 1.4698 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Slightly) | | pka | 12.24±0.10(Predicted) | | form | Adhering Crystalline Powder | | color | White to off-white | | Water Solubility | Soluble in water and alcohol. | | Sensitive | Hygroscopic | | BRN | 635683 | | Stability: | Hygroscopic | | InChIKey | KJJPLEZQSCZCKE-UHFFFAOYSA-N | | LogP | -1.82 at 20℃ | | CAS DataBase Reference | 534-03-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Amino-1,3-propanediol(534-03-2) | | EPA Substance Registry System | 1,3-Propanediol, 2-amino- (534-03-2) |
| Hazard Codes | C,Xi | | Risk Statements | 34 | | Safety Statements | 26-27-28-36/37/39-45 | | RIDADR | UN 3263 8/PG 2 | | WGK Germany | 1 | | F | 3-10-34 | | Hazard Note | Corrosive | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221990 |
| | 2-Amino-1,3-propanediol Usage And Synthesis |
| Chemical Properties | 2-amino-1, 3-propanediol, which carries the trivial name of serinol, is an organic compound from the group of alkanolamines.The name serinol was chosen because of the structural similarity to the amino acidserine. In extension, derivatives thereof with substituents on the carbons of serinol are also called serinols.Under standard conditions, it is a solid, which is very soluble in water. 2-amino-1, 3-propanediol is a very stable, hygroscopic and corrosive substance. | | Application |
- In biological field, the amino alcohol structure is widely found in many drugs especially antihistamines.
- Serinol is used as an intermediate for non-ionic X-ray contrast agents like iopamidol (1-N,3-N-bi's (1,3-dihydroxypropan-2-yl) -5-[(2S) -2-hydroxypropanamido] -2,4,6-triiodobenzene-1,3-di-carboxamide, which is for example distributed as iopamiro®, isovue® (both Bracco Diagnostics Inc.) or scanlux® (Sanochemia). Iopamidol is employed as a contrast agent for angiography throughout the cardiovascular system.
- Except the application in biochemical field, Serinol is used for the production of efficient anionic emulsifiers and nonionic polyethylene emulsions. It appears in personal care product formulations and show better base strength, lower neutral equivalent, and lower volatility than traditional amine emulsifiers.Furthermore, serinol constitutes a precursor for drugs dealing with pain treatment.
- The difunctionality of serinol makes it useful as raw materials in polymer applications in both water- and solvent-based to increase the solubility of other components and improve solution stability. It functions as a pigment dispersion-aid dispersant to enhance the wetting and viscosity stability.
- Serinol maintains a constant alkalinity in the boiling water flows and condensate not to form solid products which would impede line flow. It is applied for corrosion Inhibits. So it is widely employed in the preparation of water soluble cationic flocculants and ion exchange resins which adsorb solid and colloidal particles by electrostatic attraction. It is also used for water treatment, metal treatment and absorption of CO2 gas.
| | Chemical Properties | white to off-white adhering crystalline powder | | Uses | 2-Amino-1,3-propanediol is used as an intermediate in several chemical applications and also useful for serinol and some of its derivatives. | | Uses | Serinol may be used to prepare the artificial nucleic acids. It may be used in the synthesis of N-acylated serinol and C16-serinol affinity gel. | | General Description | Serinol activates toxin production in the attenuated cultures of Helminthosporium sacchari. Preparation of polyesters derived from serinol is reported. |
| | 2-Amino-1,3-propanediol Preparation Products And Raw materials |
| Raw materials | 1,3-DIOXANE-->2-AMINO-1,3-PROPANEDIOL OXALATE-->1,3-Dioxan-5-amine,2-phenyl-(9CI)-->1,3-Propanediol, 2,2'-iminobis--->L-Serine methyl ester hydrochloride-->DIMETHYL 2-AMINOMALONATE, TECH-->2-Nitro-1,3-propanediol-->2,5-Dihydroxy-1,4-dioxane-2,5-dimethanol | | Preparation Products | L-Serine-->Iopamidol-->2-(DiMethylaMino)propane-1,3-diol |
|
