Orcinol

Orcinol Basic information
Product Name:Orcinol
Synonyms:1,3-DIHYDROXY-5-METHYLBENZENE;1,3-Benzenediol, 5-methyl-;3,5-Dihydroxytoluene,monohydra;3,5-Orcinol;3,5-Toluenediol;3-Benzenediol,5-methyl-1;3-Hydroxy-5-methylphenol;5-methyl-3-benzenediol
CAS:504-15-4
MF:C7H8O2
MW:124.14
EINECS:207-984-2
Product Categories:Aromatic Phenols;Alcohols and Derivatives;Pyridines ,Halogenated Heterocycles;bc0001
Mol File:504-15-4.mol
Orcinol Structure
Orcinol Chemical Properties
Melting point 106-112 °C(lit.)
Boiling point 290 °C
density 1.2900
refractive index 1.4922 (estimate)
Fp 159 °C
storage temp. Store at <= 20°C.
solubility 80g/l
pka9.56±0.10(Predicted)
form Crystalline Powder or Crystals
color Pink-gray to pink-brown
Sensitive Air Sensitive
Merck 14,6864
BRN 1071903
Stability:Hygroscopic
InChIKeyOIPPWFOQEKKFEE-UHFFFAOYSA-N
LogP1.221 (est)
CAS DataBase Reference504-15-4(CAS DataBase Reference)
NIST Chemistry Reference3,5-Dihydroxytoluene(504-15-4)
EPA Substance Registry System1,3-Benzenediol, 5-methyl- (504-15-4)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-41-37/38-20/21/22
Safety Statements 22-26-36-37/39
RIDADR 2811
WGK Germany 3
RTECS VH2100000
TSCA Yes
PackingGroup III
HS Code 29072900
ToxicityLD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
MSDS Information
ProviderLanguage
1,3-Dihydroxy-5-methylbenzene English
SigmaAldrich English
ACROS English
ALFA English
Orcinol Usage And Synthesis
Chemical Propertiespink-grey to pink-brown powder or crystals.
UsesOrcinol can be used to synthesize:
Orcinol-containing azacryptands for use in optical amplifiers and light-emitting devices.
Ternary co-crystal with 4,4′-bipyridine.
Low-density carbon aerogels in the presence of formaldehyde.
PEG-orcinol coumarins with potent tyrosinase inhibitory activity.
ApplicationOrcinol is found in many lichen species and It is used as an analytical reagent for pentoses, lignin, beet sugar, saccharoses, arabinose, and diastase. The orcinol assay was used for the direct assay of the number of glycolipids presents in the sample. The orcinol reagent was prepared by adding concentrated sulphuric acid, H2SO4 (98% w/w) and 0.19% orcinol (3,5-dihydroxytoluene) to distilled water.
DefinitionChEBI: Orcinol is a 5-alkylresorcinol in which the alkyl group is specified as methyl. It has a role as an Aspergillus metabolite. It is a 5-alkylresorcinol and a dihydroxytoluene.
PreparationOrcinol has been isolated from numerous lichen fungi (Robiquet, 1829) and can be synthesized by decarboxylation of orsellinic acid in Umbilicaria papulosa and Gliocladium roseum (Pettersson, 1965; Mosbach and Ehrensvard, 1966).
Orcinol was first prepared by dehydroacetic acid, a conversion that involved ring-opening of the pyrone to a triketone. This early experiment helped establish the rich condensation chemistry of polyketides. It can be obtained by fusing extract of aloes with potash, followed by acidification.
US3865884A: Preparation of orcinol
Biological ActivityOrcinol is a compound obtained from DHA which can mimic the biogenetic synthesis of phenolic compounds.
Orcinol is a polyketide synthase-derived phenol that has been found in F. graminearum and has diverse biological activities. It scavenges DPPH radicals (IC50 = 2.93 mM). Orcinol (2.5 and 5 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity. It has also been used in the colorimetric detection of carbohydrates.
Safety ProfilePoison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. When heated to decomposition it emits acrid smoke and irritating fumes.
targetERK | BDNF
Purification MethodsCrystallise orcinol from CHCl3/*benzene (2:3). See hydrate in previous entry. [Beilstein 6 H 882, 6 IV 5892.]
PURPURIN Dodecyl gallate 3,5-Dimethoxybenzonitrile Propyl gallate Orcinol 3,4,5-Trimethoxyphenylacetonitrile Emodin 3,4-dihydro-5,6,7-trimethoxy-2-naphthoic acid 3,5-DIMETHOXYBENZOYL CHLORIDE Musk xylene Toluene 3,4,5-Trimethoxybenzonitrile METHYL-BETA-D-GALACTOPYRANOSIDE Colchicine 3,4,5-Trimethoxybenzoyl chloride Butylated Hydroxytoluene Octyl gallate 4-METHYLRESORCINOL

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