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| Product Name: | NOC-18 | | Synonyms: | DETA NONOate,97%;NOC-18;DIETHYLENETRIAMINE NONOATE;3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE;DIETHYLENETRIAMINE NONOATE;DETA/NO;DETA NONOATE;NOC-18;(Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[2-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE | | CAS: | 146724-94-9 | | MF: | C4H13N5O2 | | MW: | 163.18 | | EINECS: | | | Product Categories: | Nitric Oxide Reagents | | Mol File: | 146724-94-9.mol |  |
| | NOC-18 Chemical Properties |
| Melting point | 98-106 °C | | Boiling point | 290.26°C (rough estimate) | | density | 1.3102 (rough estimate) | | refractive index | 1.8000 (estimate) | | storage temp. | -20°C | | solubility | H2O: >20 mg/mL | | pka | 4.50±0.69(Predicted) | | form | solid | | color | off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored. | | CAS DataBase Reference | 146724-94-9 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | KH2502500 | | HS Code | 29270000 |
| | NOC-18 Usage And Synthesis |
| Description | DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0. | | Chemical Properties | White Powder | | Uses | A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours.
Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro. | | Uses | 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment. | | Definition | ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. | | Biochem/physiol Actions | 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats. | | References | 1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281 |
| | NOC-18 Preparation Products And Raw materials |
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