ChemicalBook Product Catalog Analytical Chemistry Standard Forensic and veterinary standards DROFENINE HYDROCHLORIDE

DROFENINE HYDROCHLORIDE

DROFENINE HYDROCHLORIDE Basic information
Product Name:DROFENINE HYDROCHLORIDE
Synonyms:LABOTEST-BB LT00244841;HEXAHYDROADIPHENINE HYDROCHLORIDE;DROFENINE HYDROCHLORIDE;hexahydroadiphenine;DROFENINE HCL;2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate;2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride;adipheninehhydrochloride
CAS:548-66-3
MF:C20H32ClNO2
MW:353.93
EINECS:208-954-1
Product Categories:
Mol File:548-66-3.mol
DROFENINE HYDROCHLORIDE Structure
DROFENINE HYDROCHLORIDE Chemical Properties
Melting point 145-147°
storage temp. 2-8°C
solubility Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
form Solid
color White to Off-White
Safety Information
WGK Germany 2
RTECS GU6825000
ToxicityLD50 i.v. in mice: 65.6 mg/kg (Fleisch)
MSDS Information
ProviderLanguage
SigmaAldrich English
DROFENINE HYDROCHLORIDE Usage And Synthesis
OriginatorTrasentine A,Ciba
UsesDrofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.
UsesSpasmolytic
Manufacturing Process17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.
Therapeutic FunctionSpasmolytic
DROFENINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsAdiphenine hydrochloride-->Platinum
butetamate CYCLOHEXYLPHENYLACETIC ACID DROFENINE HYDROCHLORIDE ETHYL 3-METHYLHEXANOATE ETHYL 2-PHENYLPROPIONATE ETHYL CYCLOHEXYLACETATE 3-METHYL-2-PHENYLVALERIC ACID 2-(Diethylamino)ethyl alpha-phenyl-beta-methylvalerate hydrochloride 2-DIETHYLAMINOETHANOL HYDROCHLORIDE ethyl 2-phenylbutyrate Prospasmin 2-Isopropyl-2-phenylacetic acid Cyclohexylacetic acid Drofenine ACETIC ACID, PHENYL-, 2-(DIETHYLAMINO)ETHYL ESTER METHYL CYCLOHEXANEACETATE 2-Phenylbutyric acid methyl 2-phenylbutyrate
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