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| | Ryanodine Basic information |
| Product Name: | Ryanodine | | Synonyms: | Ryanex;Ryanexcel;Ryanodine,99%;6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania;Ryanodine from Ryania speciosa;Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa;RYANODINE MIXTURE;RYANADOL | | CAS: | 15662-33-6 | | MF: | C25H35NO9 | | MW: | 493.55 | | EINECS: | 239-732-2 | | Product Categories: | Signalling;Alkaloids;InsP3/Ryanodine receptor | | Mol File: | 15662-33-6.mol |  |
| | Ryanodine Chemical Properties |
| alpha | D25 +26° (methanol) | | Boiling point | 586.95°C (rough estimate) | | density | 1.2805 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | White solid | | Melting point | 219-220 °C | | pKa | 10.66±0.70(Predicted) | | color | white to beige | | CAS DataBase Reference | 15662-33-6 | | EPA Substance Registry System | Ryanodine (15662-33-6) |
| | Ryanodine Usage And Synthesis |
| Description | Ryania insecticide is the ground stem wood of the
tropical tree Ryania speciosa Vahl., and it contains over a
dozen of several structurally related alkaloids. Nowadays,
this botanical preparation is of minor importance, but
one of its major ingredients, ryanodine, is a widely used
pharmacological tool in studies of the calcium release
channels in sarcoplasmic reticulum membranes of skeletal
and cardiac muscle of both insects and mammals (11,12). | | Chemical Properties | white to off-white solid | | Uses | Insecticide. | | Uses | Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease. | | Definition | ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa. | | Biological Activity | Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively). | | storage | -20°C (desiccate) | | References | Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968) |
| | Ryanodine Preparation Products And Raw materials |
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