ChemicalBook Product Catalog API Digestive system drugs Antacid and Mucosal protective Drugs Roxatidine

Roxatidine

Roxatidine Basic information
Product Name:Roxatidine
Synonyms:ROXATIDINE;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide;ROXATIDINE ENTERPRISE STANDARD;RoxatidineAcetateHclBase;ROXATIDINE(SUBJECTTOPATENTFREE);desacetyl-TZU-0460
CAS:78273-80-0
MF:C17H26N2O3
MW:306.4
EINECS:
Product Categories:APIs
Mol File:78273-80-0.mol
Roxatidine Structure
Roxatidine Chemical Properties
Melting point 59-60 °C
Boiling point 524.3±45.0 °C(Predicted)
density 1.137±0.06 g/cm3(Predicted)
storage temp. -20°
solubility Soluble in DMSO (up to 25 mg/ml).
pka13.34±0.10(Predicted)
form oil
color Colorless to pale yellow
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference78273-80-0(CAS DataBase Reference)
Safety Information
MSDS Information
Roxatidine Usage And Synthesis
DescriptionRoxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
UsesAnti-ulcerative.
References1) Mills and Wood (1989),?The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Pharmacol., 11 Suppl. 1?87 2) Cho?et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages; J. Cell. Biochem.,?112?3648 3) Imaeda?et al.?(2011),?Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol.,?46?1267 4) Ze?et al. (2017),?Roxatidine Attenuates Degradation of Extracellular Matrix;?Biomed. Pharmacother.,?95?1156
Propyl gallate INTERMEDIATE OF ROXATIDINE ACETATE HCL ROXATIDINE ACETATE HYDROCHLORIDE,ROXATIDINE ACETATE HCL,ROXATIDINE HCL ACETATE 2-HYDROXYACETAMIDE 3-piperidine methyl phenol (intermediatr of roxatidine) DIACETAMIDE Cimetidine Roxatidine Hydrochloride Roxatidine Acetate Hyrochloride 3-[3-piperidine methyl phenoxy propylamine (intermediatr of roxatidine) 3-(1-piperidinylmethyl)phenol (intermediate of roxatidine) ROXATIDINE OXALATE ROXATIDINE ACETATE 3-Chloropropyltriethoxysilane Propyl butyrate Roxatidine Acelate N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]amine 3-Mercaptopropyltriethoxysilane
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