(1S,2S)-(+)-Pseudoephedrine hydrochloride

(1S,2S)-(+)-Pseudoephedrine hydrochloride Basic information

Product Name:	(1S,2S)-(+)-Pseudoephedrine hydrochloride
Synonyms:	(+)-PSI-EPHEDRINE HYDROCHLORIDE;PSI-EPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL;PSEUDOEPHEDRINE HCL, (+)-1S,2S-;(+)-PSEUDOEPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HYDROCHLORIDE;a)]-;alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r,r))-benzenemethano
CAS:	345-78-8
MF:	C10H16ClNO
MW:	201.69
EINECS:	206-462-1
Product Categories:	Pharmaceutical Raw Materials;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Mol File:	345-78-8.mol

(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties

Melting point	185-188 °C(lit.)
alpha	61 º (c=5, H2O,2dm tube)
storage temp.	Refrigerator (+4°C)
solubility	Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
pka	9.22(at 25℃)
form	neat
Merck	13,8007
BRN	3915112
LogP	-1.74 at 23℃ and pH7
CAS DataBase Reference	345-78-8(CAS DataBase Reference)
EPA Substance Registry System	Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	22-36/37/38-36/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-24/25-45-36/37-16-7
RIDADR	1544
WGK Germany	3
RTECS	UL5950000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29394200
Toxicity	LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)

MSDS Information

Provider	Language
(1S,2S)-(+)-Pseudoephedrine hydrochloride	English
SigmaAldrich	English

(1S,2S)-(+)-Pseudoephedrine hydrochloride Usage And Synthesis

Chemical Properties	white powder
Uses	Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Definition	ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
Brand name	Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Contact allergens	This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical Use	Nasal decongestant
Drug interactions	Potentially hazardous interactions with other drugs Adrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers. Anaesthetics: increased risk of ventricular arrhythmias with isoflurane. Antibacterials: risk of hypertensive crisis with linezolid. Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide. Dopaminergics: avoid concomitant use with selegiline and rasagiline.
Metabolism	A small amount of pseudoephedrine is hepatically metabolised by N-demethylation. It is excreted largely unchanged in the urine with small amounts of its hepatic metabolite.
Purification Methods	1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]

(1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials

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