Cadralazine

Cadralazine Basic information

Product Name:	Cadralazine
Synonyms:	HYDRAZINECARBOXYLIC ACID, 2-[6-[ETHYL(2-HYDROXYPROPYL)AMINO]-3-PYRIDAZINYL]-, ETHYL ESTER;Cadralazine;Cadral;Cadraten;Cadrilan;CGP 18684E;DC 826;ISF 2469
CAS:	64241-34-5
MF:	C12H21N5O3
MW:	283.33
EINECS:
Product Categories:
Mol File:	64241-34-5.mol

Cadralazine Chemical Properties

Melting point	160-162°
Boiling point	425.88°C (rough estimate)
density	1.1585 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	DMSO : 250 mg/mL (882.36 mM; ultrasonic and warming and heat to 60°C)
pka	6.0(at 25℃)
CAS DataBase Reference	64241-34-5

Safety Information

Toxicity

LD50 in rats, dogs (mg/kg): 269, approx 400 i.v.; 2060, >2000 orally (Semeraro); in mice (mg/kg): 700 i.p. (Parravicini)

MSDS Information

Cadralazine Usage And Synthesis

Description	Cadralazine is a vasodilatory antihypertensive reportedly better-tolerated and longer-acting than hydralazine. It is useful as a second-line treatment in the management of hypertension.
Originator	ISF;（Smith Mine) (Italy)
Definition	ChEBI: Cadralazine is an organic molecular entity.
Brand name	Cadraten 21 cpr 20 mg;Cadraten 30 cpr 10 mg;Cadraten 30 cpr 15 mg;Cadratin;Cadrilan.
World Health Organization (WHO)	Cadralazine, a peripheral vasodilator, was introduced in 1989 for the treatment of arterial hypertension.In 1992, its association with serious side effects led to the refusal of registration in Norway. Animal experiments have demonstrated drug-related impairment of thyroid function as well as potential carcinogenicity and genotoxicity. It remains available for treatment of hypertension in Italy.

Cadralazine Preparation Products And Raw materials

Raw materials

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