ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives 2-Bromo-4-(trifluoromethyl)pyridine

2-Bromo-4-(trifluoromethyl)pyridine

2-Bromo-4-(trifluoromethyl)pyridine Basic information
Product Name:2-Bromo-4-(trifluoromethyl)pyridine
Synonyms:2-BROMO-4-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-broMo-4-(trifluoroMethyl)-;2-Bromo-alpha,alpha,alpha-trifluoro-4-picoline;2-Bromo-4-trifluormethylpyridine;2-Bromo-4-(trifluoromethyl)pyridine ISO 9001：2015 REACH
CAS:175205-81-9
MF:C6H3BrF3N
MW:225.99
EINECS:672-057-5
Product Categories:Halides;Pyridines;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
Mol File:175205-81-9.mol
2-Bromo-4-(trifluoromethyl)pyridine Structure
2-Bromo-4-(trifluoromethyl)pyridine Chemical Properties
Melting point -21--20 °C
Boiling point 84-85 °C/14 mmHg
density 1.827 g/mL at 25 °C
refractive index n20/D 1.478
Fp 164 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka-1.57±0.10(Predicted)
form clear liquid
color Colorless to Light yellow to Light orange
InChIKeyWZVHLUMAQLUNTJ-UHFFFAOYSA-N
CAS DataBase Reference175205-81-9(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 25-36/37/38-37/38-36
Safety Statements 26-36/37-45-37
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
Hazard Note Toxic/Irritant
HazardClass IRRITANT
PackingGroup Ⅲ
HS Code 2933399990
MSDS Information
ProviderLanguage
SigmaAldrich English
2-Bromo-4-(trifluoromethyl)pyridine Usage And Synthesis
Uses2-Bromo-4-(trifluoromethyl)pyridine in used in the preparation of pyrazolopyridines as kinase LRRK2 inhibitors for treating and preventing cancer and neurodegenerative diseases.
UsesRegioselective deprotonation at C-3 with LDA followed by trapping with carbon dioxide provides the correspondin nicotinic acid.
2-Bromo-4-(trifluoromethyl)pyridine Preparation Products And Raw materials
Preparation Products4,4'-bis(trifluoromethyl)-2,2'-bipyridine
2-Bromo-4-methylpyridine 2-BROMO-4-(TRIFLUOROMETHYL)NICOTINIC ACID 3-Trifluoromethylpyridine 2-Bromo-4-(trifluoromethyl)pyridine (Trifluoromethyl)trimethylsilane 4-(Trifluoromethyl)pyridine 4-Aminobenzotrifluoride 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID 2-Chloro-5-chloromethylpyridine 4-Methylpyridine Trifluoromethyl 2,6-Lutidine 2,5-Dibromo-4-(trifluoromethyl)pyridine 2-BROMO-6-METHYL-4-TRIFLUOROMETHYLPYRIDINE 2-Chloro-4-(trifluoromethyl)pyridine Lithium triflate 2-(Trifluoromethyl)pyridine 2,3-Dibromo-4-(trifluoromethyl)pyridine
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