N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE

N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE Basic information

Product Name:	N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
Synonyms:	LABOTEST-BB LT00453242;N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE;N-BOC-P-TOLUENESULFONAMIDE;N-(tert-Butoxycarbonyl-p-tolunesulfonamide;(tert-Butoxycarbonyl)tosylamine;N-(p-Tolylsulfonyl)carbamic acid tert-butyl ester;N-Tosylcarbamic acid tert-butyl ester;Tosylcarbamic acid tert-butyl ester
CAS:	18303-04-3
MF:	C12H17NO4S
MW:	271.33
EINECS:
Product Categories:	Amination;Synthetic Organic Chemistry;Nitrogen Compounds;Organic Building Blocks;Protected Amines
Mol File:	18303-04-3.mol

N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE Chemical Properties

Melting point	121-123 °C(lit.)
density	1.201±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	chloroform: soluble25mg/mL, clear, colorless
pka	4.84±0.10(Predicted)
form	powder to crystal
color	White to Almost white
InChIKey	DUTLOVSBVBGNDM-UHFFFAOYSA-N
CAS DataBase Reference	18303-04-3

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE Usage And Synthesis

Uses	N-(tert-Butoxycarbonyl)-p-toluenesulfonamide may be used in the preparation of enyne amide, precursor for Pauson-Khand reaction.
Synthesis Reference(s)	Tetrahedron Letters, 35, p. 379, 1994 DOI: 10.1016/0040-4039(94)85058-5
General Description	N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a N-substituted sulphonamide and its reaction with N-trityl L-serine esters under Mitsunobu reaction conditions is reported. It can be directly coupled with primary, secondary and allylic alcohols under Mitsunobu conditions to afford various sulfonyl-protected amines.

N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE Preparation Products And Raw materials

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