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| | 4-Chloroquinoline Basic information |
| | 4-Chloroquinoline Chemical Properties |
| Melting point | 28-31 °C (lit.) | | Boiling point | 260-261 °C (lit.) | | density | 1.25 g/mL at 20 °C (lit.) | | refractive index | 1.6110 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 3.57±0.13(Predicted) | | form | powder to lump | | color | White to Almost white | | Water Solubility | Partly soluble in water. | | λmax | 316nm(EtOH aq.)(lit.) | | BRN | 114721 | | InChIKey | KNDOFJFSHZCKGT-UHFFFAOYSA-N | | CAS DataBase Reference | 611-35-8(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Chloroquinoline(611-35-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29339900 |
| | 4-Chloroquinoline Usage And Synthesis |
| Chemical Properties | Pale yellow low melting solid | | Uses | 4-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. | | Purification Methods | Possible impurities include the 2-isomer. It is best purified by converting to the picrate (m 212-213o dec) in EtOH and recrystallising it from EtOH (where the picrate of the 2-chloroquinoline remains in solution) or EtOAc . The picrate is decomposed with 5% aqueous NaOH, extracted in CHCl3, washed with H2O, dried (MgSO4), evaporated and distilled in a vacuum. It can be steam distilled from slightly alkaline aqueous solutions, the aqueous distillate is extracted with Et2O, evaporated and distilled. The distillate solidifies on cooling. [Bobránski Chem Ber 71 578 1938, Beilstein 20/7 V 314.] |
| | 4-Chloroquinoline Preparation Products And Raw materials |
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