|
| | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Basic information |
| Product Name: | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN | | Synonyms: | glucagon-likepeptidei(7-36;H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 acetate salt;GLP-1 (7-36) amide Acetate;GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)|GLP-1 (7-36) amide(P1269);PREPROGLUCAGON (98-127) AMIDE (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT;PREPROGLUCAGON 78-107 AMIDE;PREPROGLUCAGON (78-107) AMIDE (HUMAN);PROGLUCAGON (78-107) AMIDE (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT | | CAS: | 107444-51-9 | | MF: | C149H226N40O45 | | MW: | 3297.68 | | EINECS: | | | Product Categories: | Peptide;Glucagon receptor and related | | Mol File: | 107444-51-9.mol |  |
| | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Chemical Properties |
| density | 1.47 | | RTECS | LZ3980060 | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | powder | | Water Solubility | Soluble in water (1 mg/ml). | | InChIKey | DTHNMHAUYICORS-KTKZVXAJSA-N |
| | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Usage And Synthesis |
| Uses | Diabetes?II?-?not?yet?an?approved?application | | Uses | Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist:
- in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activity
- to pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeleton
- to test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries
| | Uses | Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. | | General Description | Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide. | | Biochem/physiol Actions | GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus. | | storage | Store at -20°C |
| | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Preparation Products And Raw materials |
|
