ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Basic information
Product Name:(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Synonyms:(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;Intedanib Impurity D;Nintedanib Impurity 34;Nintedanib-011;Nintedanib impurity 10/(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)meth...;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-;Nintedanib Impurity q
CAS:1987887-92-2
MF:C24H21N3O3
MW:399.44
EINECS:
Product Categories:
Mol File:1987887-92-2.mol
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Structure
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties
Melting point 273 - 276°C
Boiling point 641.3±55.0 °C(Predicted)
density 1.316±0.06 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka11.16±0.20(Predicted)
form Solid
color Yellow to Orange
Safety Information
MSDS Information
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Usage And Synthesis
Uses(3Z)?-2,?3-Dihydro-?3-?[[[4-?(methylamino)?phenyl]?amino]?phenylmethylene]?-?2-?oxo-?1H-?Indole-?6-?carboxylic Acid Methyl Ester is an impurity of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate 1-Chloro-4-(trimethoxymethyl)benzene 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide Methyl oxindole-5-carboxylate 4'-Amino-N-methylacetanilide 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester P-ANISALDEHYDE DIMETHYL ACETAL 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Nintedanib Methyl 4-chloro-3-nitrobenzoate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide Methyl 1-acetyl-2-oxoindoline-6-carboxylate (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester METHYL OXINDOLE-7-CARBOXYLATE
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