4-Chloroanisole

4-Chloroanisole Basic information
Product Name:4-Chloroanisole
Synonyms:1-chloro-4-methoxy-benzen;4-Chloroanisol;4-Chlorophenol methyl ether;Anisole, p-chloro-;Benzene,1-chloro-4-methoxy-;p-chloroanisol;p-Chloromethoxybenzene;p-Chlorophenyl methyl ether
CAS:623-12-1
MF:C7H7ClO
MW:142.58
EINECS:210-772-2
Product Categories:Aromatic Ethers;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds;623-12-1
Mol File:623-12-1.mol
4-Chloroanisole Structure
4-Chloroanisole Chemical Properties
Melting point ?18 °C (lit.)
Boiling point 198-202 °C (lit.)
density 1.164 g/mL at 25 °C (lit.)
vapor pressure 1.08hPa at 25℃
refractive index n20/D 1.535(lit.)
Fp 173 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
color Clear colorless to yellow
Water Solubility immiscible
BRN 1858901
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
LogP2.78 at 25℃
CAS DataBase Reference623-12-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, 1-chloro-4-methoxy-(623-12-1)
EPA Substance Registry SystemBenzene, 1-chloro-4-methoxy- (623-12-1)
Safety Information
Hazard Codes Xn
Safety Statements 23-24/25
RIDADR UN 2810
WGK Germany 3
TSCA Yes
HS Code 29093090
MSDS Information
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4-Chloroanisole English
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4-Chloroanisole Usage And Synthesis
Chemical Propertiescolourless liquid
Uses4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.
Synthesis Reference(s)Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060
General Description4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.
Purification MethodsWash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]
4-BROMO-2-CHLOROANISOLE 2-AMINO-4-CHLOROANISOLE DIAZOTATED ZINCDOUBLE SALT,2-AMINO-4-CHLOROANISOLE DIAZOTATED ZINC CHLORIDE COMPLEX 4-Bromo-3-chloroanisole 99%,4-BROMO-3-CHLOROANISOLE 5-Acetamido-2-chloroanisole CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER 4-AMINOMETHYL-2-CHLOROANISOLE HYDROCHLORIDE,4-AMINOMETHYL-2-CHLOROANISOLE HCL 2-Bromo-3-chloroanisole Dimefluthrin 4-[(6-bromohexyl)oxy]-3-chloroanisole 3-Bromo-2-chloroanisole 2-amino-4-chloroanisole hydrochloride 2-Acetylamino-5-chloroanisole 2-METHYL-5-CHLOROANISOLE 4-CHLOROANISOLE-2,3,5,6-D4 p-Dichlorobenzene 3-Methoxy-4-chloroanisole 2-AMINO-5-CHLOROANISOLE HYDROCHLORIDE,2-Amino-5-chloroanisole 4-CHLOROPHENYL CHLOROFORMATE

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