Cyclopenthiazide

Cyclopenthiazide Basic information
Product Name:Cyclopenthiazide
Synonyms:2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dih;3-cyclopentylmethylhydrochlorothiazidederiv;cyclomethiazide;navidrix;salimed;salimid;su8341;tsiklometiazid
CAS:742-20-1
MF:C13H18ClN3O4S2
MW:379.88
EINECS:212-012-5
Product Categories:Aromatics;Heterocycles;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:742-20-1.mol
Cyclopenthiazide Structure
Cyclopenthiazide Chemical Properties
Melting point 230°
Boiling point 605.6±65.0 °C(Predicted)
density 1.3650 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. Refrigerator
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka9.00±0.40(Predicted)
form Solid
color White to Off-White
Water Solubility 50mg/L(room temperature)
CAS DataBase Reference742-20-1(CAS DataBase Reference)
EPA Substance Registry System2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1)
Safety Information
ToxicityLD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)
MSDS Information
Cyclopenthiazide Usage And Synthesis
UsesCyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
UsesAntihypertensive;Sodium Chloride Symporter Inhibitor
DefinitionChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.
World Health Organization (WHO)Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Clinical UseThiazide diuretic:
Hypertension

Heart failure

Oedema




Drug interactionsPotentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised.
Antibacterials: avoid administration with lymecycline.
Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics.
Antiepileptics: increased risk of hyponatraemia with carbamazepine.
Antifungals: increased risk of hypokalaemia with amphotericin.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia occurs.
Ciclosporin: increased risk of nephrotoxicity and possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias due to hypokalaemia with arsenic trioxide; increased risk of nephrotoxicity and ototoxicity with platinum compounds.
Lithium: excretion reduced, increased toxicity



MetabolismCyclopenthiazide appears to be entirely excreted unchanged in the urine.
Cyclopenthiazide Preparation Products And Raw materials
Cyclopenthiazide Phenothiazine butizide 4-CHLORO-1,3-BENZENEDITHIOL CLOFENAMIDE PUROMYCIN DIHYDROCHLORIDE Buprofezin thiazine Thiamethoxam Benzo[b]thien-2-ylboronic acid Hydrochlorothiazide Difluorochloromethane 2-AMINO-N-BUTYLBENZENESULFONAMIDE Cyclopentene ethiazide Dihydromyrcenol 2-amino-N-propylbenzenesulfonamide 4-Amino-6-chlorobenzene-1,3-disulfonamide

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