2-(4-Chlorophenoxy)-2-methylpropionic acid

2-(4-Chlorophenoxy)-2-methylpropionic acid Basic information

Product Name:	2-(4-Chlorophenoxy)-2-methylpropionic acid
Synonyms:	CLOFIBRIC ACID;4-Chorophenoxy-d-methylpropionicacid;4-CPIB;Chlorobenzene oxygenisobutyrate;Acetic acid, (p-chlorop;Prestwick_39;2-(4-Chlorophe;Acetic acid, (p-chlorophenoxy)dimethyl-
CAS:	882-09-7
MF:	C10H11ClO3
MW:	214.65
EINECS:	212-925-9
Product Categories:	Organic acids;Aromatics Compounds;Acids and Derivatives;Aromatics;Intermediates & Fine Chemicals;Intracellular receptor;Pharmaceuticals;CLOFIBRIN;882-09-7
Mol File:	882-09-7.mol

2-(4-Chlorophenoxy)-2-methylpropionic acid Chemical Properties

Melting point	120-122 °C(lit.)
Boiling point	308.11°C (rough estimate)
density	1.2413 (rough estimate)
refractive index	1.5220 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
pka	3.18±0.10(Predicted)
form	Crystals or Crystalline Powder
color	Pale yellow to brownish
Merck	14,2378
BRN	1874067
CAS DataBase Reference	882-09-7(CAS DataBase Reference)
NIST Chemistry Reference	Clofibric acid(882-09-7)
EPA Substance Registry System	Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7)

Safety Information

MSDS Information

2-(4-Chlorophenoxy)-2-methylpropionic acid Usage And Synthesis

Description	Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC₅₀ = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent.
Chemical Properties	Pale Yellow Solid
Uses	Antilipemic.
Uses	herbicide, antihyperlipoproteinemic, antineoplastic
Uses	A hypolipidemic compound
Definition	ChEBI: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Biological Activity	PPAR agonist. Antihyperlipoproteinemic.

2-(4-Chlorophenoxy)-2-methylpropionic acid Preparation Products And Raw materials

Raw materials	O-(4-chlorophenyl)hydroxylamine-->plafibride-->Chlorobutanol-->4-CHLOROPHENOL SODIUM SALT-->N-Acetyl-L-cysteine-->4-Chlorophenol-->Ethyl 2-bromoisobutyrate-->Acetone-->Chloroform-->Acetamide
Preparation Products	Clofibrate-->etofibrate 2-hydroxymethylnicotinate-->Nicotinic acid

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