ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 1(2H)-Phthalazinone

1(2H)-Phthalazinone

1(2H)-Phthalazinone Basic information
Product Name:1(2H)-Phthalazinone
Synonyms:BENZO[D]PYRIDAZIN-1(2H)ONE;2H-Phthalazin-1-one;1(2H)-Phthalazinone, 98+%;1,2-Dihydrophthalazine-1-one;Pthalazone;1,2-Dihydro-1-oxophthalazine, Benzo[d]pyridazin-1(2H)-one, Phthalazone;1(2H)-Phthalazinone, 98+% 5GR;Benzo[d]pyridazin-1(2H)one 1(2H)-Phthalazinone
CAS:119-39-1
MF:C8H6N2O
MW:146.15
EINECS:204-319-8
Product Categories:Aldehyde;Miscellaneous
Mol File:119-39-1.mol
1(2H)-Phthalazinone Structure
1(2H)-Phthalazinone Chemical Properties
Melting point 183-185 °C(lit.)
Boiling point 337°C(lit.)
density 1.2312 (rough estimate)
refractive index 1.4900 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka12.29±0.20(Predicted)
form Crystalline Powder
color Off-white to pale yellow
BRN 3654
InChIKeyIJAPPYDYQCXOEF-UHFFFAOYSA-N
CAS DataBase Reference119-39-1(CAS DataBase Reference)
EPA Substance Registry System1(2H)-Phthalazinone (119-39-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-68-36/37/38
Safety Statements 22-24/25-36/37/39-26
WGK Germany 3
RTECS TH9185000
HazardClass IRRITANT
HS Code 29339990
Hazardous Substances Data119-39-1(Hazardous Substances Data)
Toxicitymouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00139,
MSDS Information
ProviderLanguage
Benzo[d]pyridazin-1(2H)one English
SigmaAldrich English
1(2H)-Phthalazinone Usage And Synthesis
Chemical PropertiesOff-white to pale yellow crystalline powder
UsesPhthalazone is a remarkable scaffold in drug discovery. Also, functions as an oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.
DefinitionChEBI: Phthalazin-1(2H)-one is a member of phthalazines.
General DescriptionPale yellow crystals. Insoluble in water.
Air & Water ReactionsInsoluble in water.
Fire HazardFlash point data for 1(2H)-Phthalazinone are not available. 1(2H)-Phthalazinone is probably combustible.
Purification MethodsPhthalazone crystallises from H2O or EtOH and sublimes in vacuo. [Beilstein 24 H 142, 24 24 III/IV 400.]
1(2H)-Phthalazinone Preparation Products And Raw materials
Raw materialsPotassium permanganate-->Hydrazine sulfate-->Benzoylformic acid
Preparation Products1-CHLOROPHTHALAZINE-->1(2H)-Phthalazinone, 2-(2-propyn-1-yl)--->2-methylphthalazin-1-one
3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER 3-(4-CHLOROPHENYL)-N-(4-METHOXYPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 2-tert-Butyl-4,5-dichloro-3-2H-pyridazinone (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 4-OXO-3-PHENYL-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 4-METHYLPHTHALAZIN-1(2H)-ONE 3-(4-CHLOROPHENYL)-4-OXO-N-[4-(TRIFLUOROMETHOXY)PHENYL]-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 2-AMINOPHTHALYLHYDRAZIDO-N-ACETYL-B-D-GLUCOSAMINIDE 4-(4-CHLOROPHENYL)-1-(2H)-PHTHALAZINONE& 3-(4-CHLOROPHENYL)-N-(2,4-DIFLUOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1H-azepin-4-yl)-1(2H)-phthalazinone ETHYL 2-(3-([4-(TERT-BUTYL)-1,3-THIAZOL-2-YL]METHYL)-4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETATE 2-{4-nitrophenyl}-4-methyl-1(2H)-phthalazinone 3-(4-METHOXYPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 3-(4-FLUOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE 4-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxoethyl}-2-methyl-1(2H)-phthalazinone 4-OXO-3-[3-(TRIFLUOROMETHYL)PHENYL]-3,4-DIHYDRO-1-PHTHALAZINECARBOXAMIDE
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