Rimantadine hydrochloride

Rimantadine hydrochloride Basic information
Product Name:Rimantadine hydrochloride
Synonyms:FLUMADINE;IFLAB-BB F1386-0449;MERADANE;1-(1-aminoethyl)adamantane hydrochloride;1-(1-ADAMANTYL)ETHANAMINE HYDROCHLORIDE;1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE;ALPHA-METHYL-1-ADAMANTANEMETHYLAMINE HYDROCHLORIDE;ROFLUAL
CAS:1501-84-4
MF:C12H22ClN
MW:215.76
EINECS:604-725-9
Product Categories:Adamantane derivatives;Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Anti-viral Compounds;Adamantanes;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals
Mol File:1501-84-4.mol
Rimantadine hydrochloride Structure
Rimantadine hydrochloride Chemical Properties
Melting point >300 °C(lit.)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly), Water(Slightly)
form Solid
color White to Off-White
Water Solubility Freely soluble in water.
Merck 14,8224
InChIKeyOZBDFBJXRJWNAV-UHFFFAOYSA-N
CAS DataBase Reference1501-84-4
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS AU4717000
HS Code 29213000
ToxicityLD50 oral in rat: 640mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
Rimantadine hydrochloride Usage And Synthesis
DescriptionRimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.
Chemical PropertiesWhite Crystalline Solid
OriginatorDuPont (USA)
UsesRimantadine Hydrochloride is used as an antiviral agent.
DefinitionChEBI: Rimantadine hydrochloride is an organic molecular entity.
Brand nameFlumadine (Forest);Roflual.
references[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.
[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.
Rimantadine hydrochloride Preparation Products And Raw materials
Raw materialsLithium Aluminum Hydride-->Mercuric Oxide-->Vinyl bromide-->Adamantane-->RIMANTADINE HCL USP(CRM STANDARD)
Acetaminophen 1-(Methoxyacetylamino) Adamantane (MAAA) Pentoxyverine Amantadine Cefixime 1-Adamantanamine hydrochloride Triethylamine hydrochloride Ethambutol dihydrochloride Rimantadine hydrochloride Adamantane RIMANTADINE HCL USP(CRM STANDARD) 2-Chloroethylamine hydrochloride Topotecan hydrochloride 2-(2-Aminoethylamino)ethanol Ethylamine hydrochloride 1-Adamantanemethylamine 1-AdaMantanethylaMine Ethylamine

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