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| | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Basic information |
| Product Name: | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester | | Synonyms: | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester;1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-diMethylethyl ester;tert-Butyl 3,5-dioxopiperidine-1-carboxylat;5-dioxopiperidine-1-carboxylate;N-Boc-3,5-dioxopiperidine;1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-dimethylethyl e...;1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-dimethylethyl ester (9CI, ACI);3,5-dioxo-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI) | | CAS: | 396731-40-1 | | MF: | C10H15NO4 | | MW: | 213.23 | | EINECS: | | | Product Categories: | | | Mol File: | 396731-40-1.mol |  |
| | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Chemical Properties |
| Boiling point | 346.2±32.0 °C(Predicted) | | density | 1.199±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | 9.72±0.20(Predicted) | | color | Light yellow to yellow | | CAS DataBase Reference | 396731-40-1 |
| | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Usage And Synthesis |
| Uses | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
To a cooled (5 ??C) and stirred mixture of potassium 2-methyl-2-propoxide (29.7 g,0.27 mol) was added a solution of ethyl [A/-((1,1-dimethylethoxy)carbonyl),A/-(2-oxopropyl)]glycinate (65 g, 0.25 mol) in ethyl ether (200 ml) over a period of 1.5 h. The re- sulting mixture was stirred for an additional 3 h, and the formed precipitate was filtered offand washed with ethyl ether (2 x 100 ml). The solid was dissolved in water (150 ml), andacetic acid was added to adjust the pH to 4. The product was filtered, washed with water (2x 50 ml) and air dried to furnish 1 -[(1,1 -dimethylethoxy)carbonyl]-3,5-dioxopiperidine (28 g,52 %).>xxN'TOHPLC-MS: m/z: 158 (M+H-56).1H-NMR (DMSO-d6): 81.48 (9H, s), 4.03 (4H, s), 5.38 (1 H, s). |
| | 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Preparation Products And Raw materials |
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