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| | ELASTATINAL Basic information |
| Product Name: | ELASTATINAL | | Synonyms: | N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;elastatinal from microbial source;L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer;Leu-co-cpd-Gln-Ala-h;L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-;(2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide;AIDS-006470;Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide | | CAS: | 51798-45-9 | | MF: | C21H36N8O7 | | MW: | 512.56 | | EINECS: | 257-426-7 | | Product Categories: | Enzymes;Inhibitors;Miscellaneous Peptides;Organic Building Blocks;P to Q;Peptides and Proteins;Blood Proteins;Peptides for Cell Biology;Plasmin;Protease Inhibitor Specificity Index;Protease Inhibitors;Proteins and Derivatives;Pepetides;peptides;Plasma &;Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Coagulation Proteins and Reagents;E;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme | | Mol File: | 51798-45-9.mol |  |
| | ELASTATINAL Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 20 mg/mL, clear, yellow | | form | Yellow solid. | | color | off-white | | BRN | 873543 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | LZ9600000 | | F | 10 |
| | ELASTATINAL Usage And Synthesis |
| Description | Elastatinal is a potent inhibitor of pancreatic elastase (Ki = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands. | | Uses | Elastatinal is an elastase inhibitor. | | Biochem/physiol Actions | Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes. | | References | 1) Umezawa et al. (1973), Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes; J. Antibiotics, 26 787
2) Nakajima et al. (1992), Identification of elastase as a secretory protease from cultured rat microglia; J. Neurochem., 58 1401
3) Molla et al. (1993), Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteases by elastase-specific inhibitors; J. Virol., 67 4688
4) Menendez-Arias et al. (1992), Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines; J. Biol. Chem., 267 11392 |
| | ELASTATINAL Preparation Products And Raw materials |
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