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DISUCCINIMIDYL SUBERATE

DISUCCINIMIDYL SUBERATE Basic information
Product Name:DISUCCINIMIDYL SUBERATE
Synonyms:SUBERIC ACID BIS(N-HYDROXY-SUCCINIMIDE ESTER);DSS Crosslinker;Di(N-succinimidyl) Suberate;DISUCCINIMIDYL OCTANEDIOATE;DISUCCINIMIDYL SUBERATE;DSS;n-hydroxysuccinimidesubericacidester;Bis-(N-succinimidyl)-suberate
CAS:68528-80-3
MF:C16H20N2O8
MW:368.34
EINECS:614-576-1
Product Categories:Homobifunctional Crosslinker;homoXlink;ADC LINKER
Mol File:68528-80-3.mol
DISUCCINIMIDYL SUBERATE Structure
DISUCCINIMIDYL SUBERATE Chemical Properties
Melting point 169-170°C
Boiling point 513.5±60.0 °C(Predicted)
density 1.295 g/cm3
storage temp. 2-8°C
solubility chloroform: 50 mg/mL
form powder
color White to Almost white
Water Solubility Insoluble in water. Soluble in chloroform: 50 mg/mL.
InChIKeyZWIBGKZDAWNIFC-UHFFFAOYSA-N
CAS DataBase Reference68528-80-3
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29171900
MSDS Information
ProviderLanguage
SigmaAldrich English
DISUCCINIMIDYL SUBERATE Usage And Synthesis
DescriptionDSS Crosslinker is a membrane permeable, noncleavable crosslinker. The NHS ester groups are reactive toward primary amines.
UsesSuberic acid bis(N-hydroxysuccinimide ester) has been:
  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

UsesDisuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.
UsesDisuccinimidyl suberate is a homobifunctional amine-reactive crosslinker. It is usually coupled to molecules containing primary amines via amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates an 8-atom spacer arm.
General DescriptionSuberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.
DISUCCINIMIDYL SUBERATE Preparation Products And Raw materials
Raw materialsSuberic acid-->N-Hydroxysuccinimide
Suberate Bis(sulfosuccinimidyl) Sodium Salt N-Succinimidyl maleimidoacetate DISULFOSUCCINIMIDYL TARTRATE Suberic acid BS3 4-Maleimidobenzoic acid Polysuccinimide DISUCCINIMIDYL SEBACATE ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N- EGS Crosslinker 2-Maleimido acetic acid 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 4-(N-Maleimido)benzophenone Azelaic acid 4-(MALEINIMIDO)PHENYL ISOCYANATE* Glycolic acid BS3 DISUCCINIMIDYL SUBERATE
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