ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 2-PIPERIDYLMETHYLAMINE

2-PIPERIDYLMETHYLAMINE

2-PIPERIDYLMETHYLAMINE Basic information
Product Name:2-PIPERIDYLMETHYLAMINE
Synonyms:1-(Piperidin-2-yl)methylamine;1-piperidin-2-ylmethanamine;2-AMINOMETHYL PIPERIDINE 99%;piperidin-2-ylmethanamine;2-PIPERIDYLMETHYLAMI;2 - Methyl piperidine aMMonia;(RS)-1-(Piperidin-2-yl)methanamine;2-Amino-methyl-priperidine
CAS:22990-77-8
MF:C6H14N2
MW:114.19
EINECS:245-371-1
Product Categories:Piperidine;Amines;Piperidines, Piperidones, Piperazines;Piperazine;Building Blocks;Heterocyclic Building Blocks;Piperidines
Mol File:22990-77-8.mol
2-PIPERIDYLMETHYLAMINE Structure
2-PIPERIDYLMETHYLAMINE Chemical Properties
Boiling point 63-66°C/12mm
density 0.9406 g/mL at 25 °C
refractive index 1.4850
Fp 63-66°C/12mm
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka10.32±0.29(Predicted)
form neat
color Clear Colorless
BRN 102994
InChIKeyRHPBLLCTOLJFPH-UHFFFAOYSA-N
CAS DataBase Reference22990-77-8(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR 2735
WGK Germany 2
HazardClass 8
PackingGroup III
HS Code 29333990
MSDS Information
2-PIPERIDYLMETHYLAMINE Usage And Synthesis
Uses2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.
UsesReactant for reversible aminal formation

Reactant for synthesis of:
  • Annulated N-heterocyclic carbene ligands
  • M3 Muscarinic receptor antagonists
  • Selective 5-ht5A receptor antagonists
  • Ternary platinum(II) complexes
Purification MethodsDry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.]
2-PIPERIDYLMETHYLAMINE Preparation Products And Raw materials
Raw materials2-Picolylamine-->Diethyl ether-->Water-->Hydrochloric acid-->2-Cyanopyridine
Preparation ProductsFlecainide
VERRUCULOGEN PIPECOLYLDITHIOCARBAMIC ACID PIPECOLINIUM SALT BRL 52537 HYDROCHLORIDE 2-PIPERIDYLMETHYLAMINE Bupivacaine hydrochloride NPC-15437 DIHYDROCHLORIDE Ropivacaine Bupivacaine 2-ACETAMIDO-1,2,5-TRIDEOXY-1,5-IMINO-D-G LUCITOL AF-DX 384, [2,3-DIPROPYLAMINO-3H]- 2-(2-DIETHYLAMINOETHYL)PIPERIDINE 1-(2-PIPERIDYLMETHYL)PYRROLE AJMALINE Mepivacaine hydrochloride DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE Mepivacaine 1-PIPERIDIN-2-YLMETHYL-PIPERIDINE FLECAINIDE ACETATE
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