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| | dolasetron Basic information |
| Product Name: | dolasetron | | Synonyms: | (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate;Dolasteron;Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-;Dolasetronum;Dolasetronum [inn-latin];Hsdb 7565;Unii-82wi2L7Q6e | | CAS: | 115956-12-2 | | MF: | C19H20N2O3 | | MW: | 324.37 | | EINECS: | | | Product Categories: | API;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 115956-12-2.mol |  |
| | dolasetron Chemical Properties |
| Melting point | 278 ºC | | Boiling point | 535.1±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) | | pka | 15.36±0.30(Predicted) | | form | Solid | | color | White | | Water Solubility | Soluble | | CAS DataBase Reference | 115956-12-2 |
| | dolasetron Usage And Synthesis |
| Description | Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea. | | Chemical Properties | White Solid | | Uses | prevention and treatment of postoperative nausea and vomiting | | Uses | Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
| | Uses | Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic. | | Definition | ChEBI: LSM-5418 is an indolyl carboxylic acid. | | Brand name | Anzemet (Sanofi Aventis. |
| | dolasetron Preparation Products And Raw materials |
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