Tetramethylthiourea

Tetramethylthiourea Basic information
Product Name:Tetramethylthiourea
Synonyms:TETRAMETHYLTHIOUREA;1,1,3,3-TETRAMETHYL-2-THIOUREA;((CH3)2N)2CS;1,1,3,3-tetramethyl-2-thio-ure;Basthioryl;N,N,N',N'-Tetramethylthiourea;Tetramethylthiourea Synonyms N,N,N',N'-Tetramethylthiourea;1,1,3,3-TetraMethyl-2-thiourea, 98% 25GR
CAS:2782-91-4
MF:C5H12N2S
MW:132.23
EINECS:220-488-0
Product Categories:Heterocycles;Organic Building Blocks;Sulfur Compounds;Thioureas;2782-91-4
Mol File:2782-91-4.mol
Tetramethylthiourea Structure
Tetramethylthiourea Chemical Properties
Melting point 75-77 °C (lit.)
Boiling point 245 °C (lit.)
density 1.005 (estimate)
refractive index 1.5300 (estimate)
Fp 190 °C
storage temp. 2-8°C
solubility 32g/l
form solid
pka1.50±0.50(Predicted)
color Off-White to Pale Beige
Water Solubility 32 g/L (20 ºC)
BRN 1744916
InChIKeyMNOILHPDHOHILI-UHFFFAOYSA-N
CAS DataBase Reference2782-91-4(CAS DataBase Reference)
NIST Chemistry ReferenceThiourea, tetramethyl-(2782-91-4)
EPA Substance Registry SystemTetramethylthiourea (2782-91-4)
Safety Information
Hazard Codes Xn
Risk Statements 22-20/21/22
Safety Statements 22-24/25-36
WGK Germany 3
RTECS YU2750000
TSCA Yes
HS Code 29309070
Hazardous Substances Data2782-91-4(Hazardous Substances Data)
MSDS Information
ProviderLanguage
1,1,3,3-Tetramethyl-2-thiourea English
SigmaAldrich English
ACROS English
ALFA English
Tetramethylthiourea Usage And Synthesis
Chemical PropertiesCOLORLESS TO YELLOW CRYSTALLINE CHUNKS
UsesAs a drug.
UsesTetramethylthiourea forms BF3 adduct with tetramethylselenourea.
DefinitionChEBI: Tetramethylthiourea is a member of thioureas.
General DescriptionWhite crystals.
Air & Water ReactionsWater soluble.
Reactivity ProfileAn organosulfide amide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
HazardModerately toxic by ingestion.
Fire HazardFlash point data for Tetramethylthiourea are not available, but Tetramethylthiourea is probably combustible.
Safety ProfileModerately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and teratogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES.
Tetramethylthiourea Preparation Products And Raw materials
ETHYL 3-ACETYL-1,6-DIMETHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE 1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DITHIONE 1-(3,4-DIMETHYLPHENYL)-3-PHENYL-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE MTH-DL-PROLINE THIOUREA 1-CARBOXYMETHYL-3-PHENYL-5-(2-(3-ETHYL-2-BENZOXAZOLINYLIDENE)-ETHYLIDENE)-THIOHYDANTOIN PHENYLTHIOHYDANTOIN-PROLINE PTH-L-PROLINE 1-PHENYL-2-THIOUREA 1,3-DIMETHYL-5-[(1-METHYL-2-PYRROLIDINYLIDENE)ETHYLIDENE]-2-THIOXO-4-IMIDAZOLIDINONE AKOS B029106 1,3-DIMETHYL-2-THIOHYDANTOIN Thibenzazoline 5-(aminomethylene)-1,3-diphenyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione LABOTEST-BB LT00154569 MEROCYANINE 540 PTH-4-HYDROXYPROLINE AKOS B029084

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