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| | Ethyl nitroacetate Basic information |
| | Ethyl nitroacetate Chemical Properties |
| Boiling point | 105-107 °C/25 mmHg (lit.) | | density | 1.199 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.424(lit.) | | Fp | 198 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Liquid | | pka | pK1:5.85 (25°C) | | color | Clear colorless to slightly yellow | | Water Solubility | Slightly soluble in water. Soluble in chloroform and ethyl acetate. | | BRN | 1210027 | | InChIKey | FTKASJMIPSSXBP-UHFFFAOYSA-N | | CAS DataBase Reference | 626-35-7(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, nitro-, ethyl ester(626-35-7) | | EPA Substance Registry System | Acetic acid, nitro-, ethyl ester (626-35-7) |
| Hazard Codes | Xi | | Risk Statements | 38 | | Safety Statements | 23-24/25-37 | | WGK Germany | 2 | | RTECS | AJ1074000 | | Hazard Note | Irritant | | TSCA | T | | HazardClass | IRRITANT, KEEP COLD | | HS Code | 29159080 |
| | Ethyl nitroacetate Usage And Synthesis |
| Chemical Properties | clear colourless to slightly yellow liquid | | Uses | Ethyl Nitroacetate is an ester of nitrocarboxylic acid used as an intermediate in the preparation of unsubstituted amino acids. | | Uses | Ethyl nitroacetate has been used in the synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones, fuctionalization of C4-position on pyrimidine and C6-position on 2?-deoxyguanosine to produce novel nucleosides, facile synthesis of α,α-diisobutylglycine, synthesis of DL-4,4-difluoroglutamic acid. It is also used as an intermediate in the preparation of unsubstituted amino acids. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 59, p. 1208, 1994 DOI: 10.1021/jo00084a047 | | Purification Methods | Purify the ester by repeated distillation. IR:max 1748 (CO2), 1570 and 1337 (NO2), and 800cm-1 [Haszeldine J Chem Soc 2525 1953]. The hydrazine salt crystallises from 95% EtOH or MeOH as yellow crystals m 104-105o [Ungnade & Kissinger J Org Chem 22 1661 1957, Emmons & Freeman J Am Chem Soc 77 4391 1955]. [Beilstein 2 IV 537.] |
| | Ethyl nitroacetate Preparation Products And Raw materials |
| Raw materials | Pentanedioic acid, 2-nitro-3-oxo-, 1,5-diethyl ester-->TERT-BUTYL ETHYL MALONATE-->tert-Butanol-->Propanedioic acid,1-ethyl 3-methyl ester-->Propanoic acid, 3-[(4-methoxyphenyl)amino]-3-oxo-, ethyl ester-->ALFA-NITRO ACETIC ACID-->Acetic acid, 2-chloro-2-nitro-, ethyl ester-->3-oxo-3-(propylamino)Propanoic acid ethyl ester-->ethyl2-nitro-3-oxobutanoate-->diethyl 1,2,5-oxadiazole-3,4-dicarboxylate 2-oxide-->Ethyl iodoacetate-->Ethyl cyanoformate-->ethyl glycinate-->Ethyl glycolate-->ETHYL AZIDOACETATE | | Preparation Products | 4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE-->3-FLUORO-DL-TYROSINE-->4-HYDROXY-5-NITROPYRIMIDINE-->2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER |
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