Isosorbide

Isosorbide Basic information
Product Name:Isosorbide
Synonyms:Dianhydro-D-glucitol 98%;1,4:3,6-DIANHYDRO-D-SORBITOL;1,4:3,6-DIANHYDROGLUCITOL;1,4:3,6-DIANHYDROSORBITOL;1,4:3,6-DIANHYDRO-D-GLUCITOL;D-ISOSORBIDE;DIANHYDRO-D-GLUCITOL;DIANHYDRO-D-SORBITOL
CAS:652-67-5
MF:C6H10O4
MW:146.14
EINECS:211-492-3
Product Categories:Carbohydrates & Derivatives;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Food Additivies;11;Inhibitors;652-67-5
Mol File:652-67-5.mol
Isosorbide Structure
Isosorbide Chemical Properties
Melting point 60-63 °C (lit.)
alpha 42 º (c=3, H2O)
Boiling point 175°C/2mmHg(lit.)
density 1.0945 (rough estimate)
vapor pressure 0.007Pa at 20℃
refractive index 45 ° (C=5, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka13.17±0.40(Predicted)
form Crystals, Crystalline Solid or Mass
color Off-white to light yellow or beige
optical activity[α]20/D +45.2°, c = 3 in H2O
Water Solubility Soluble in alcohols, water and ketones.
Sensitive Hygroscopic
Merck 14,5224
BRN 80510
InChIKeyKLDXJTOLSGUMSJ-JGWLITMVSA-N
LogP-1.39 at 20℃
CAS DataBase Reference652-67-5(CAS DataBase Reference)
EPA Substance Registry SystemD-Glucitol, 1,4:3,6-dianhydro- (652-67-5)
Safety Information
Risk Statements 22
Safety Statements 24/25
WGK Germany 2
RTECS LZ4380000
TSCA Yes
HS Code 29349990
Hazardous Substances Data652-67-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Isosorbide Usage And Synthesis
Chemical Propertiesoff-white to light yellow or beige crystals,
UsesIsosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
Usespharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.
UsesD-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.
DefinitionA polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.
Brand nameIsmotic (Alcon).
Biological Functionsemergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.
Flammability and ExplosibilityNonflammable
Clinical UseIsosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.
Isosorbide dimethyl ether Isosorbide dinitrate ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE Isosorbide-2-Acetate Isosorbide dioleate Isosorbide 6,3-GLUCURONOLACTONE ACETONIDE D(+)-Glucose Isosorbide dinitrate U.S.P24,BP98,Diluted isosorbide dinitrate Isosorbide dinitrate mixture with not less than 60% lactose,mannose,starch or calcium hydrogen phosphate,Mixed isosorbide dinitrate 8-BENZYLOXYISOSORBIDE TRIPHENYLPHOSPHOYLIDE D-Glucurono-6,3-lactone acetonide Aceglatone ISOSORBIDE-13C6 DINITRATE Sornidipine Sorbitol 5-CHLOROACETOXY-2-BENZYLOXYISOSORBIDE Ammonium carbonate

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