| Uses | NP40 Cell Lysis Buffer is suitable for the preparation of cell extracts to be analyzed by Antibody Bead Immunoassay (Luminex), ELISA, and Western blotting. It can also be used as a wash buffer for immunoprecipitation reactions. |
| Uses | Arkopal? N 100 is a nonionic surfactant that can be used for testing the stress cracking resistance of polyethylene materials at high temperatures. It is also suitable for enhancing the biodegradation of aromatic hydrocarbon compounds. |
| General Description | with approx. 10 ethylene oxide units |
| Biochem/physiol Actions | ERK2 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of ERK2 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK2 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK2 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta). |
| Safety Profile | Moderately toxic by
ingestion and skin contact. A severe eye and
mild skin irritant in humans. Many glycol
ethers cause dangerous human reproductive
effects. When heated to decomposition it emits acrid smoke and irritating fumes. See
also GLYCOL ETHERS. |
