Di-tert-Butyl malonate

Di-tert-Butyl malonate Basic information
Product Name:Di-tert-Butyl malonate
Synonyms:Propanedioic acid, bis(1,1-dimethylethyl) ester;propanedioicacid,bis(1,1-dimethylethyl)ester;Di-tert-Butyl malote;DI-TERT-BUTYL MALONATE;DI-T-BUTYL MALONATE;bis(1,1-dimethylethyl) malonate;MALONIC ACID DI-T-BUTYL ESTER;Di-t-butyl malonate, 98+%
CAS:541-16-2
MF:C11H20O4
MW:216.27
EINECS:208-769-6
Product Categories:Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C10 to C11;Carbonyl Compounds;Esters;bc0001
Mol File:541-16-2.mol
Di-tert-Butyl malonate Structure
Di-tert-Butyl malonate Chemical Properties
Melting point -7--6 °C (lit.)
Boiling point 110-111 °C/22 mmHg (lit.)
density 0.966 g/mL at 25 °C (lit.)
refractive index n20/D 1.418(lit.)
Fp 88 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
pka11.87±0.46(Predicted)
form Liquid
color Clear colorless to slightly yellow
Water Solubility It is hardly soluble in water.
Merck 14,3034
BRN 1781766
InChIKeyCLPHAYNBNTVRDI-UHFFFAOYSA-N
CAS DataBase Reference541-16-2(CAS DataBase Reference)
NIST Chemistry Referencedi-tert-Butyl malonate(541-16-2)
EPA Substance Registry SystemPropanedioic acid, bis(1,1-dimethylethyl) ester (541-16-2)
Safety Information
Risk Statements 36/37/38-24/25
Safety Statements 23-24/25
WGK Germany 3
TSCA Yes
HS Code 29171910
MSDS Information
ProviderLanguage
Malonic acid di-tert-butyl ester English
SigmaAldrich English
ACROS English
ALFA English
Di-tert-Butyl malonate Usage And Synthesis
Chemical Propertiesclear colorless to slightly yellow liquid
UsesDi-tert-butyl malonate was used in total synthesis of (+/?)-actinophyllic acid. It was also employed as precursor for metal-organic chemical vapor deposition of HfO2 and ZrO2 thin films.
UsesIn the preparation of ketones.
UsesDi-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T
Di-tert-Butyl malonate Preparation Products And Raw materials
Preparation ProductsPazufloxacin-->2-Diazomalonic acid ditert-butyl ester-->tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-b]pyridine-4(5H)-carboxylate-->N-(1,1-Dimethylethyl)-3-methylbenzamide
3-ACETYL-3,8,8-TRIMETHYL-2,7-DIOXASPIRO[4.4]NONANE-1,6-DIONE Z-DL-GLA(OTBU)2-OH FMOC-D-GLA(OTBU)2-OH 3-(2-AMINO-1,3-THIAZOL-4-YL)-3,8,8-TRIMETHYL-2,7-DIOXASPIRO[4.4]NONANE-1,6-DIONE Z-D-GLA(OTBU)2-OH 3-tert-Butoxy-3-oxopropanoic acid 3-[2-(ALLYLAMINO)-1,3-THIAZOL-4-YL]-3,8,8-TRIMETHYL-2,7-DIOXASPIRO[4.4]NONANE-1,6-DIONE 3,3,8-TRIMETHYL-8-{2-[(4-METHYLPHENYL)AMINO]-1,3-THIAZOL-4-YL}-2,7-DIOXASPIRO[4.4]NONANE-1,6-DIONE Buprofezin FMOC-TYR(MALONYL-DI-OTBU)-OH Butylmalonic acid BUTYL OLEATE BOC-D-GLA(OTBU)2-OH MALONIC ACID DI-N-BUTYL ESTER propanedioate Z-L-GLA(OTBU)2-OH FMOC-DL-GLA(OTBU)2-OH BOC-L-GLA(OTBU)2-OH

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