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| | Dihydroresveratrol Basic information |
| Product Name: | Dihydroresveratrol | | Synonyms: | Dihydroresveratrol;3,4',5-Trihydroxybibenzyl;4-[2-(3,5-Dihydroxyphenyl)ethyl]phenol;5-[2-(4-Hydroxyphenyl)ethyl]benzene-1,3-diol;Dihydroresveratol;α,β-Dihydrostilbene-3,4',5-triol;5-[2-(4-hydroxyphenyl)ethyl]-1,3-benzenediol;3,5,4'-Trihydroxybibenzyl | | CAS: | 58436-28-5 | | MF: | C14H14O3 | | MW: | 230.26 | | EINECS: | | | Product Categories: | Phenols | | Mol File: | 58436-28-5.mol |  |
| | Dihydroresveratrol Chemical Properties |
| Melting point | 155-157°C | | Boiling point | 430.3±14.0 °C(Predicted) | | density | 1.291±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 30 mg/ml). | | pka | 9.51±0.10(Predicted) | | form | solid | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | Dihydroresveratrol Usage And Synthesis |
| Description | Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3?Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4?Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5?Inactive analog of resveratrol in induction of premature senescence.6 | | Uses | Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are detectable in urine. The physiological effects of dihydroresveratrol have not been investigated. | | Uses | Dihydroresveratrol is a natural phytoestrogen. | | Definition | ChEBI: Dihydroresveratrol is a stilbenol that is 1,1'-ethane-1,2-diyldibenzene with hydroxy groups at positions 1, 3 and 4'. It has a role as a xenobiotic metabolite and a plant metabolite. | | References | 1) Jung?et al.?(2009),?Interaction of dietary resveratrol with animal-associated bacteria; FEMS Microbiol. Lett.,?297?266
2) Bode?et al.?(2013),?In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota; Am. J. Clin. Nutr.,?97?295
3) Jarosova?et al.?(2019),?Metabolism of Stilbenoids by Human Faecal Microbiota; Molecules,?24?E1155
4) Radco?et al.?(2013),?Semi-preparative isolation of dihydroresveratrol-3-O-?-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 930?54
5) Oode?et al.?(2014),?Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells; Eur. J. Med. Chem.,?87?862
6) Faragher?et al.?(2011),?Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts; Age (Dordr.),?33?555 |
| | Dihydroresveratrol Preparation Products And Raw materials |
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