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| | 5-FLUORO-2-PICOLINIC ACID Basic information |
| | 5-FLUORO-2-PICOLINIC ACID Chemical Properties |
| Melting point | 164-166℃ | | Boiling point | 275.1±20.0 °C(Predicted) | | density | 1.419±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 3.58±0.10(Predicted) | | color | White to Light yellow to Light orange | | InChIKey | JTKFIIQGMVKDNZ-UHFFFAOYSA-N | | CAS DataBase Reference | 107504-08-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 5-FLUORO-2-PICOLINIC ACID Usage And Synthesis |
| Synthesis | Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).
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| | 5-FLUORO-2-PICOLINIC ACID Preparation Products And Raw materials |
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