ChemicalBook Product Catalog Chemical Reagents Organic reagents Sulfonyl halide 1-Butanesulfonyl chloride

1-Butanesulfonyl chloride

1-Butanesulfonyl chloride Basic information
Product Name:1-Butanesulfonyl chloride
Synonyms:BUTANESULFONYLCHLORIDE;1-Butanesulfonyl Chloride, 98.0%(T);1-Butanesulfonic acid chloride;Butane-1-sulfonic acid chloride;1-Butanesulfonyl chloride,99%;1-(Chlorosulphonyl)butane;Butanesulphonyl chloride;1-Butanesulfonyl chloride, 99% 25GR
CAS:2386-60-9
MF:C4H9ClO2S
MW:156.63
EINECS:219-204-8
Product Categories:Pharmaceutical Intermediates;Sulfonyl Halides;Sulfur Compounds;Organic Building Blocks
Mol File:2386-60-9.mol
1-Butanesulfonyl chloride Structure
1-Butanesulfonyl chloride Chemical Properties
Melting point -29°C
Boiling point 80-81 °C/9 mmHg (lit.)
density 1.208 g/mL at 25 °C (lit.)
vapor pressure 0.5 mm Hg ( 20 °C)
refractive index n20/D 1.454(lit.)
Fp 175 °F
form Liquid
color Clear colorless to light yellow or light orange
Water Solubility DECOMPOSES
Sensitive Moisture Sensitive
BRN 1748742
InChIKeyWEDIIKBPDQQQJU-UHFFFAOYSA-N
CAS DataBase Reference2386-60-9(CAS DataBase Reference)
NIST Chemistry Reference1-Butanesulfonyl chloride(2386-60-9)
EPA Substance Registry System1-Butanesulfonyl chloride (2386-60-9)
Safety Information
Hazard Codes C
Risk Statements 34-36/37
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS EK5950000
F 10-19-21
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29049090
Toxicitymouse,LD50,intraperitoneal,> 100mg/kg (100mg/kg),Nature. Vol. 174, Pg. 737, 1954.
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
1-Butanesulfonyl chloride Usage And Synthesis
Chemical Propertiesclear colourless to light yellow liquid
Uses1-Butanesulfonyl chloride has been used in the preparation of:
  • ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
  • 1-butanesulfonamid-N,N′-1,2-ethanediylbis
  • 1-butanesulfonamide-N,N′-1,3-propanediylbis
Purification MethodsIt has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]
1-Butanesulfonyl chloride Preparation Products And Raw materials
Preparation ProductsTirofiban-->Nonafluorobutanesulfonyl fluoride-->4-chlorobutane-1-sulphonyl chloride-->Sodium 1-butanesulfonate
TIROFIBAN HYDROCHLORIDE MONOHYDRATE 4-(4-Piperidyl)-1-butanol Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) 2-butyl-4-methylpyridine L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE 1-Methylethyl 1-butanesulfonate 1-Butanesulfonic acid methyl ester N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine 4-(4-pyridinyl)butyl chloride hydrochloride Pyridine, 4-(4-bromobutyl)- (9CI) R-Tirofiban Ammonium carbonate additive 1,4-BUTANEDISULFONYLCHLORIDE BUTANE-2-SULFONYL CHLORIDE 4-Chloro-1-butanesulfonyl chloride 4-Fluoro-1-butanesulfonyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile 1-HEXANESULFONYL CHLORIDE
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