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| Methyltriphenylphosphonium bromide Basic information |
| Methyltriphenylphosphonium bromide Chemical Properties |
Hazard Codes | Xn,Xi | Risk Statements | 20/21/22-36/37/38 | Safety Statements | 36/37-36-26 | RIDADR | UN 1390 4.3/PG 2 | WGK Germany | 3 | Autoignition Temperature | 410 °C | TSCA | T | HazardClass | 6.1 | PackingGroup | III | HS Code | 29310095 | Toxicity | LD50 orally in Rabbit: 118 mg/kg |
| Methyltriphenylphosphonium bromide Usage And Synthesis |
Chemical Properties | white powder | Uses | PTC catalyst | Uses | Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. It is a lipophilic molecule and used to deliver molecules to specific cell components. Further, it acts as an antineoplastic agent. | Uses | Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.
| General Description | Methyltriphenylphosphoniumbromide is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis.
Mettler-Toledo calibration substance ME 30130598, methyltriphenylphosphoniumbromide is ideal for use in the regular calibration of Mettler-Toledo melting point instrument. Its value is a mean of 6 to 12 iterations with a Mettler-Toledo MP70 Excellence instrument that is calibrated against primary standards. The melting point is validated by Capillary method according to European Pharmacopeia (2.2.14.) | Purification Methods | If the solid is sticky, wash it with *C6H6 and dry it in a vacuum over P2O5. [Marvel & Gall J Org Chem 24 1494 1959, Chem Ber 87 1318 1954, Milas & Priesing J Am Chem Soc 79 6295 1957, Wittig & Sch.llkopf Org Synth 40 66 1960.] The iodide, on recrystallisation from H2O, has m 187.5-188.5o [Mann et al. J Chem Soc 1130 1953, Wittig & Geissler Justus Liebigs Ann Chem 580 44 1953]. [Beilstein 16 IV 981.] |
| Methyltriphenylphosphonium bromide Preparation Products And Raw materials |
Raw materials | Triphenylphosphine-->Methyl bromide | Preparation Products | 4-Fluorostyrene-->4-Chloro-alpha-methylstyrene-->alpha-cyclopropylstyrene-->Cyclohexene, 2-ethenyl-1,3,3-trimethyl--->9-Decenoic acid, methyl ester-->4-VINYLBENZYL ACETATE-->4-IODOSTYRENE-->Benzoic acid, 2-ethenyl- (9CI)-->2-Hydroxystyrene-->1-Piperidinecarboxylic acid, 3-Methylene-, phenylMethyl ester-->Benzene, 1-ethenyl-2-(1-Methylethoxy)--->P-TRIMETHYLSILYL STYRENE-->4,4'-VINYLIDENEBIS(N,N-DIMETHYLANILINE)-->3-VINYLBENZALDEHYDE-->2-methylenepropane-1,3-diyl diacetate |
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