Isocyclosporin A

Isocyclosporin A Basic information
Product Name:Isocyclosporin A
Synonyms:30-ethyl-34-[(Z)-hex-4-en-2-yl]-4,7,10,12,15,19,25,28-octamethyl-33-me thylamino-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1-oxa- 4,7,10,13,16,19,22,25,28,31-decazacyclotetratriacontane-2,5,8,11,14,17 ,20,23,26,29,32-undecone;isocyclosporin A;Cyclo[L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-[(3R,4R)-3-hydroxy*-N-methyl-5-[(E)-1-propenyl]-L-Leu-]];L-Valine, N-(3-hydroxy-4-methyl-2-(methylamino)-1-oxo-6-octenyl)-L-(alpha-aminobutyryl)-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-, theta1-1actone, (2S-(2R*,3S*,4S*,6E))-;(2S,3R,4R,6E)-3-Hydroxy-4-Methyl-2-(MethylaMino)-6-octenoyl-(2S)-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl-L-alanyl-D-alanyl-N-Methyl-L-leucyl-N-Methyl-L-leucyl-N-Methyl-L-valine (111)-Lactone;[2S-(2R*,3S*,4S*,6E)]-N-[3-Hydroxy-4-methyl-2-(methylamino)-1-oxo-6-octenyl]-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valine theta1-lactone;IsoCyclosporine;Cyclosporin Impurity 9
CAS:59865-16-6
MF:C62H111N11O12
MW:1202.61
EINECS:
Product Categories:Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
Mol File:59865-16-6.mol
Isocyclosporin A Structure
Isocyclosporin A Chemical Properties
Melting point 148-152°C
Boiling point 1280.5±65.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka13.42±0.70(Predicted)
form Solid
color White to Off-White
Stability:Hygroscopic
InChIKeyQEKLELUAISGHEL-VWEOAMRINA-N
Safety Information
MSDS Information
Isocyclosporin A Usage And Synthesis
Chemical PropertiesWhite Solid
UsesCyclosporin A (C988900) impurity.
UsesIsocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention.
Isocyclosporin A Preparation Products And Raw materials
CYCLOSPORINE RESOLUTION MIXTURE (25 MG) ISOLIQUIRITIN ISORHYNCHOPHYLLINE HOMOORIENTIN 10-(N-Methyl-D-valine)isocyclosporin A DIHYDROCYCLOSPORIN A CYCLOSPORIN D Ifosfamide TRIS(2,2,2-TRIFLUOROETHYL)ORTHOFORMATE 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one Isoliquiritigenin Isocyclosporin A H-LEU-GLY-OET HCL

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