ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Glutamic acid derivatives Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Basic information
Product Name:Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate
Synonyms:n-[[5-(methylamino)-2-thienyl]carbonyl]-l-glutamic acid diethyl ester;diethyl n-[5-methylamino-2-thenoyl]-l-glutamate;(S)-Diethyl 2-(5-(MethylaMino)thiophene-2-carboxaMido)pentanedioate;L-Glutamic acid, N-[[5-(methylamino)-2-thienyl]carbonyl]-, 1,5-diethyl ester;iethyl(2S)-2-[[5-(methylamino)thiophene-2-carbonyl]amino]pentanedioate;Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate USP/EP/BP
CAS:112889-02-8
MF:C15H22N2O5S
MW:342.41
EINECS:
Product Categories:Raltitrexed
Mol File:112889-02-8.mol
Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure
Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Chemical Properties
Boiling point 519.6±50.0 °C(Predicted)
density 1.231
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka12.89±0.46(Predicted)
Safety Information
MSDS Information
Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Usage And Synthesis
UsesN-[[5-(Methylamino)-2-thienyl]carbonyl]-L-glutamic Acid Diethyl Ester can be used as reactant/reagent for synthetic preparation of Raltitrexed (anticancer agent). An intermediate or impurity in the synthesis of Raltitrexed (R100500). Raltitrexed (R100500) is folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic.
Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Preparation Products And Raw materials
Preparation ProductsDiethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate
Thienyl Glutamic acid Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Glutamate Benzocaine 2-AMINODIETHYLMALONATE PYRAZOPHOS L-Glutamic acid Urethane Diethyl oxalate CARBONYL SULFIDE ETHYL 3-AMINOCROTONATE Diethyl ether Mefenpyr-diethyl P-AMINOBENZAMIDE GLUTAMIC ACID Celiprolol Diethyl malonate Ethylene glycol diethyl ether
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