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| | Tryptophol Basic information |
| | Tryptophol Chemical Properties |
| Melting point | 56-59 °C(lit.) | | Boiling point | 174 °C (2.02527 mmHg) | | density | 1.0840 (rough estimate) | | refractive index | 1.5200 (estimate) | | Fp | 255 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | methanol: 0.1 g/mL, clear | | pka | 15.16±0.10(Predicted) | | form | Crystalline Mass, Crystals, Flakes or Powder | | color | Off-white to brown | | Water Solubility | 10 g/L (20 ºC) | | Merck | 14,9798 | | BRN | 125553 | | InChIKey | MBBOMCVGYCRMEA-UHFFFAOYSA-N | | LogP | 1.280 (est) | | CAS DataBase Reference | 526-55-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-indole-3-ethanol(526-55-6) | | EPA Substance Registry System | 1H-Indole-3-ethanol (526-55-6) |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | KL3685000 | | F | 8 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29339990 | | Toxicity | LD50 intraperitoneal in mouse: 351mg/kg |
| | Tryptophol Usage And Synthesis |
| Chemical Properties | off-white to brown crystalline mass, crystals, | | Uses | Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation. | | Uses | Reactant for preparation of:
- Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
- Anti-HIV-1 agents
- Inhibitors of Protein-Protein Interactions
- Partial agonists of the serotonin 5-HT1A receptor
- Growth hormone secretagogues
- Vascular endothelial growth factor (VEGF) inhibitors
- A2B adenosine receptor ligands
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- Inhibitors of interleukine 6
- Dual binding site acetylcholinesterase inhibitors
| | Definition | ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2. | | Synthesis Reference(s) | Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070 | | Purification Methods | Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.] |
| | Tryptophol Preparation Products And Raw materials |
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