N-Carbobenzyloxy-L-aspartic acid

N-Carbobenzyloxy-L-aspartic acid Basic information

Product Name:	N-Carbobenzyloxy-L-aspartic acid
Synonyms:	Z-ASPARTIC ACID;Z-ASP;Z-L-ASPARTIC ACID;Z-L-ASP-OH;n-[(phenylmethoxy)carbonyl]-l-aspartic acid;L-ASPARTIC ACID, N-[(PHENYLMETHOXY)CARBONYL]-;CBZ-ASP-OH;CBZ-L-ASP
CAS:	1152-61-0
MF:	C12H13NO6
MW:	267.23
EINECS:	214-568-4
Product Categories:	Aspartic acid [Asp, D];Z-Amino Acids and Derivatives;Amino Acid Derivatives;PROTECTED AMINO ACID & PEPTIDES;Amino Acids;Amino Acids (N-Protected);Protected Amino Acids;Biochemistry;Cbz-Amino Acids;Chiral Compounds;Z-Amino acid series
Mol File:	1152-61-0.mol

N-Carbobenzyloxy-L-aspartic acid Chemical Properties

Melting point	117-119 °C (lit.)
alpha	10.5 º (c=1,AcOH)
Boiling point	410.42°C (rough estimate)
density	1.3276 (rough estimate)
refractive index	9.5 ° (C=7, AcOH)
storage temp.	2-8°C
solubility	almost transparency in Methanol
pka	3.75±0.23(Predicted)
form	Fine Crystalline Powder
color	White
optical activity	[α]23/D +8.6°, c = 7 in acetic acid
BRN	2336722
CAS DataBase Reference	1152-61-0(CAS DataBase Reference)
EPA Substance Registry System	N-Carbobenzyloxy-L-aspartic acid (1152-61-0)

Safety Information

MSDS Information

Provider	Language
N-(Benzyloxycarbonyl)-L-aspartic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Carbobenzyloxy-L-aspartic acid Usage And Synthesis

Chemical Properties	white fine crystalline powder
Uses	N-Cbz-L-aspartic acid is an N-Cbz-protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.

N-Carbobenzyloxy-L-aspartic acid Preparation Products And Raw materials

Raw materials	3(2H)-Oxazolecarboxylic acid, 2-oxo-, phenylmethyl ester-->L-Aspartic acid, bis(trimethylsilyl) ester-->N-Cbz-L-Aspartic acid 4-tert-butyl ester-->(S)-diMethyl 2-(((benzyloxy)carbonyl)aMino)succinate-->Z-ASP(OME)-OH-->L-Aspartic acid-->Benzyl chloroformate-->Benzyl alcohol
Preparation Products	(R)-benzyl 2,5-dioxotetrahydrofuran-3-ylcarbamate-->methyl 3-phenyl-L-alaninate-->N-CARBOBENZYLOXY-L-ASPARTIC ANHYDRIDE-->Butanoic acid, 4-amino-4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, (3S)-

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